How to cite this article: Vila M, Cicuéndez M, Sánchez-Marcos J, Fal-Miyar V, Manzano M, Prieto C, Vallet-Regi M. 2013. Electrical stimuli to increase cell proliferation on carbon nanotubes/mesoporous silica composites for drug delivery. J Biomed Mater Res Part A 2013:101A:213–221.
Electrical stimuli to increase cell proliferation on carbon nanotubes/mesoporous silica composites for drug delivery†
Article first published online: 30 JUL 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 101A, Issue 1, pages 213–221, January 2013
How to Cite
Vila, M., Cicuéndez, M., Sánchez-Marcos, J., Fal-Miyar, V., Manzano, M., Prieto, C. and Vallet-Regi, M. (2013), Electrical stimuli to increase cell proliferation on carbon nanotubes/mesoporous silica composites for drug delivery. J. Biomed. Mater. Res., 101A: 213–221. doi: 10.1002/jbm.a.34325
- Issue published online: 23 NOV 2012
- Article first published online: 30 JUL 2012
- Manuscript Revised: 8 JUL 2012
- Manuscript Accepted: 21 JUN 2012
- Manuscript Received: 3 MAY 2012
- Marie Curie European Reintegration Grant. Grant Number: FP7-PEOPLE-2007-2-2-ERG
- Spanish CICYT. Grant Number: MAT2008-00736
- CAM. Grant Number: S-0505/MAT/0324
- Spanish Ministry of Science and Innovation. Grant Number: CS/2010-11384-E
- MEC, Ramón y Cajal and Juan de la Cierva Grants
- carbon nanotubes;
- cell stimulation;
- mesoporous silica;
- drug delivery
The development of smart materials as bone implants is nowadays a challenging task to optimize their fast osteointegration. Nevertheless, no attempts have been done in joining the possibility of using electrical stimulation and drug delivery together in a material intended for bone tissue engineering. Moreover, the use of this synergy to induce bone healing is still limited until novel drug reservoirs material formulations allow an efficient applicability of the electrical stimuli. Herein, we present the biological response of osteoblasts cells, cultured over carbon nanotubes–mesoporous silica composites while exposed to external electrical stimulus. Moreover, its ability to function as drug delivery systems is also demonstrated. Bone cell metabolism was stimulated and mitochondrial activity was increased up to seven times in the presence of these composites under electrical stimulus, suggesting their potential application in bone regeneration processes. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A:213–221, 2013.