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Electrical stimuli to increase cell proliferation on carbon nanotubes/mesoporous silica composites for drug delivery

Authors

  • M. Vila,

    Corresponding author
    1. Department of Inorganic and Bioinorganic Chemistry, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, Madrid 28040, Spain
    2. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain
    • Department of Inorganic and Bioinorganic Chemistry, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, Madrid 28040, Spain
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  • M. Cicuéndez,

    1. Department of Inorganic and Bioinorganic Chemistry, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, Madrid 28040, Spain
    2. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain
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  • J. Sánchez-Marcos,

    1. Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, Madrid 28049, Spain
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  • V. Fal-Miyar,

    1. Department of Inorganic and Bioinorganic Chemistry, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, Madrid 28040, Spain
    2. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain
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  • M. Manzano,

    1. Department of Inorganic and Bioinorganic Chemistry, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, Madrid 28040, Spain
    2. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain
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  • C. Prieto,

    1. Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, Madrid 28049, Spain
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  • M. Vallet-Regi

    1. Department of Inorganic and Bioinorganic Chemistry, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, Madrid 28040, Spain
    2. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain
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  • How to cite this article: Vila M, Cicuéndez M, Sánchez-Marcos J, Fal-Miyar V, Manzano M, Prieto C, Vallet-Regi M. 2013. Electrical stimuli to increase cell proliferation on carbon nanotubes/mesoporous silica composites for drug delivery. J Biomed Mater Res Part A 2013:101A:213–221.

Abstract

The development of smart materials as bone implants is nowadays a challenging task to optimize their fast osteointegration. Nevertheless, no attempts have been done in joining the possibility of using electrical stimulation and drug delivery together in a material intended for bone tissue engineering. Moreover, the use of this synergy to induce bone healing is still limited until novel drug reservoirs material formulations allow an efficient applicability of the electrical stimuli. Herein, we present the biological response of osteoblasts cells, cultured over carbon nanotubes–mesoporous silica composites while exposed to external electrical stimulus. Moreover, its ability to function as drug delivery systems is also demonstrated. Bone cell metabolism was stimulated and mitochondrial activity was increased up to seven times in the presence of these composites under electrical stimulus, suggesting their potential application in bone regeneration processes. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A:213–221, 2013.

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