Get access

Facile graft of poly(2-methacryloyloxyethyl phosphorylcholine) onto Fe3O4 nanoparticles by ATRP: Synthesis, properties, and biocompatibility

Authors

  • Xiao-Yan Sun,

    1. Laboratory of Functional and Biomedical Nanomaterials, College of Materials Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China
    Search for more papers by this author
  • Shou-Shan Yu,

    1. Laboratory of Functional and Biomedical Nanomaterials, College of Materials Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China
    Search for more papers by this author
  • Jia-Qi Wan,

    1. Laboratory of Functional and Biomedical Nanomaterials, College of Materials Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China
    Search for more papers by this author
  • Ke-Zheng Chen

    Corresponding author
    1. Laboratory of Functional and Biomedical Nanomaterials, College of Materials Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China
    • Laboratory of Functional and Biomedical Nanomaterials, College of Materials Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China
    Search for more papers by this author

  • How to cite this article: Sun X-Y, Yu S-S,Wan J-Q, Chen K-Z. 2013. Facile graft of poly(2-methacryloyloxyethyl phosphorylcholine) onto Fe3O4 nanoparticles by ATRP: Synthesis, properties, and biocompatibility. J Biomed Mater Res Part A 2013: 101A:607–612.

Abstract

Magnetite (Fe3O4) nanoparticles with the surface hydroxyl groups were achieved by a polyol process. Using 2-(4-chlorosulfonylphenyl) ethyltrichlorosilane (CTCS) as initiator, 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) as monomer, poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC)-grafted Fe3O4 nanoparticles (MNP) were successfully prepared via the atom transfer radical polymerization (ATRP) method. The successful grafting of PMPC on the Fe3O4 nanoparticles surface was ascertained from the FTIR analysis. The modified nanoparticles (MNP-CTCS-PMPC) showed a good biocompatibility in the cytotoxicity test in vitro. Performance testing of MNP-CTCS-PMPC was performed through magnetic resonance analysis (MR), and its r2/r1 value was 24.1. These results indicated that the modified Fe3O4 nanoparticles would be a potential MRI contrast reagent. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

Ancillary