Dopamine-assisted immobilization of hydroxyapatite nanoparticles and RGD peptides to improve the osteoconductivity of titanium

Authors


  • How to cite this article: Chien C-Y, Liu T-Y, Kuo W-H, Wang M-J, Tsai W-B. 2013. Dopamine-assisted immobilization of hydroxyapatite nanoparticles and RGD peptides to improve the osteoconductivity of titanium. J Biomed Mater Res Part A 2013:101A:740–747.

Abstract

Hydroxyapatite (HAp) coating on orthopedic implants is a common strategy to increase osteointegration. In this work, a facile deposition method based on dopamine polymerization was developed for preparation of HAp-coated titanium substrates for orthopedic applications. Nanostructured HAp was mixed with an alkaline dopamine solution and then deposited onto titanium to form a dopamine/HAp ad-layer. The deposition of dopamine/HAp greatly enhanced the adhesion, proliferation, and mineralization of osteoblasts. Furthermore, RGD-containing peptides were immobilized to dopamine/HAp coated titanium and further enhanced cell adhesion and osteogenic differentiation. In conclusion, this facile dopamine-assisted surface modification method shows a great potential for orthopedic and dental applications. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 740–747, 2013.

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