Polyurethanes containing zwitterionic sulfobetaines and their molecular chain rearrangement in water

Authors

  • Jun Cao,

    1. College of Polymer Science and Engineering of Sichuan University, Sichuan University, Sichuan 610065, People's Republic of China
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  • Mou Yang,

    1. State Key Lab of Oil and Gas Geology and Exploration, Southwest Petroleum University, Chengdu 610500, People's Republic of China
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  • Aijing Lu,

    1. College of Polymer Science and Engineering of Sichuan University, Sichuan University, Sichuan 610065, People's Republic of China
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  • Shuying Zhai,

    1. College of Polymer Science and Engineering of Sichuan University, Sichuan University, Sichuan 610065, People's Republic of China
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  • Yuanwei Chen,

    1. College of Polymer Science and Engineering of Sichuan University, Sichuan University, Sichuan 610065, People's Republic of China
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  • Xianglin Luo

    Corresponding author
    1. College of Polymer Science and Engineering of Sichuan University, Sichuan University, Sichuan 610065, People's Republic of China
    2. State Key Lab of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China
    • College of Polymer Science and Engineering of Sichuan University, Sichuan University, Sichuan 610065, People's Republic of China
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  • How to cite this article: Cao J, Yang M, Lu A, Zhai S, Chen Y, Luo X, 2013: Polyurethanes containing zwitterionic sulfobetaines and their molecular chain rearrangement in water. J Biomed Mater Res Part A 2013:101A:909–918.

Abstract

Novel polyurethanes with zwitterionic sulfobetaines, termed PUR-APS, were designed and synthesized by chain-extension of biodegradable poly(ε-caprolactone) containing N,N′-bis (2-hydroxyethyl) methylamine ammonium propane sulfonate (PCL-APS) with hexamethylene diisocyanate (HDI). The bulk properties of polymers were characterized by nuclear magnetic resonance spectrum (NMR), Fourier transform infrared spectroscopy (FTIR), gel permeation chromatograph (GPC), and differential scanning calorimetry (DSC). Results showed that the polymers were successfully synthesized. Water contact angles (WCAs) and X-ray photoelectron spectroscopy (XPS) revealed that molecular chains of the polymers rearranged after soaking in water. The amount of protein adsorption, determined by bicinchoninic acid (BCA) assay, was less than 300 ng/cm2 and decreased after hydration. The blood compatibility of the polymers was evaluated by the degree of hemolytic and activated partial thromboplastic time (APTT) and prothrombin time (PT). Results indicated that PUR-APS polymers had good blood compatibility. Therefore, polyurethanes containing sulfobetaines have a great potential for biomedical application. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 909–918, 2013.

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