Plasma treatment of electrospun PCL random nanofiber meshes (NFMs) for biological property improvement

Authors

  • D. Yan,

    1. Department of Polymer Materials Science and Engineering, College of Materials Science and Engineering, and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, China
    2. Department of Mechanical and Aerospace Engineering, Center for Surface Science and Plasma Technology, University of Missouri, Columbia, Missouri 65211
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  • J. Jones,

    1. Department of Mechanical and Aerospace Engineering, Center for Surface Science and Plasma Technology, University of Missouri, Columbia, Missouri 65211
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  • X.Y. Yuan,

    1. Department of Polymer Materials Science and Engineering, College of Materials Science and Engineering, and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, China
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  • X.H. Xu,

    1. Department of Polymer Materials Science and Engineering, College of Materials Science and Engineering, and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, China
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  • J. Sheng,

    1. Department of Polymer Materials Science and Engineering, College of Materials Science and Engineering, and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, China
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  • J.C.-M. Lee,

    1. Department of Biological Engineering, University of Missouri, Columbia, Missouri 65211
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  • G.Q. Ma,

    1. Department of Polymer Materials Science and Engineering, College of Materials Science and Engineering, and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, China
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  • Q.S. Yu

    Corresponding author
    1. Department of Mechanical and Aerospace Engineering, Center for Surface Science and Plasma Technology, University of Missouri, Columbia, Missouri 65211
    • Department of Mechanical and Aerospace Engineering, Center for Surface Science and Plasma Technology, University of Missouri, Columbia, Missouri 65211
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  • How to cite this article: Yan D, Jones J, Yuan XY, Xu XH, Sheng J, Lee JC-M, Ma GQ, Yu QS. 2013. Plasma treatment of electrospun PCL random nanofiber meshes (NFMs) for biological property improvement. J Biomed Mater Res Part A 2013:101A:963–972.

Abstract

In this article, the plasma surface modification effects on the chemical, mechanical, and biological properties of electrospun poly (ε-caprolactone) (PCL) random nanofiber meshes (NFMs) were investigated by adjusting plasma chemistry, that is, using glow discharges of N2+H2, NH3+O2, and Ar+O2 gas mixtures. The surface property changes of electrospun PCL NFMs after those plasma treatments were examined by water contact angle measurements and X-ray photoelectron spectroscopy. The experimental results showed that the plasma treatments introduced polar groups onto the surfaces and thus increased the surface hydrophilicity. From tensile test data, plasma treatment had limited effect on the mechanical properties of PCL random NFMs. The biological properties of the plasma-treated PCL NFMs were examined by cell proliferation assays using mouse osteoblast cells (MC3T3-E1). It was found that the plasma-treated PCL NFMs gave a higher proliferation rate and improved cell adhesion properties as compared with the untreated controls. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

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