Electrical signals guided entrapment and controlled release of antibiotics on titanium surface

Authors

  • Xiaowen Shi,

    Corresponding author
    1. Department of Environmental Science, School of Resource and Environmental Science, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430079, China
    • Department of Environmental Science, School of Resource and Environmental Science, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430079, China
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  • Huiping Wu,

    1. Department of Environmental Science, School of Resource and Environmental Science, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430079, China
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  • Yuanyuan Li,

    1. Institute of Environmental Medicine, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
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  • Xiaoquan Wei,

    1. Department of Environmental Science, School of Resource and Environmental Science, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430079, China
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  • Yumin Du

    1. Department of Environmental Science, School of Resource and Environmental Science, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430079, China
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  • How to cite this article: Shi X, Wu H, Li Y, Wei X, Du Y. 2013. Electrical signals guided entrapment and controlled release of antibiotics on titanium surface. J Biomed Mater Res Part A 2013:101A:1373–1378.

Abstract

Electrical signals are used to trigger the entrapment and release of antibiotics on the surface of titanium plate. The entrapment of antibiotics relies on the electrochemically induced pH gradient generated at the titanium surface that allows the gelation of an aminopolysaccharide chitosan and codeposition of vancomycin, a common antibiotic, within chitosan gel. The release of vancomycin is controlled by an anodic signal imposed to the titanium plate that causes a pH decrease and erosion of chitosan gel. We show that the on demand entrapment and release of vancomycin at the surface of titanium plate is fundamentally altered and controlled by voltage. We expect that this rapid, mild and facile electrochemical process for antibiotics loading and release will find applications in controlled drug release from titanium implants. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

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