How to cite this article: Kraitzer A, Alperstein D, Kloog Y, Zilberman M. 2013. Mechanisms of antiproliferative drug release from bioresorbable porous structures. J Biomed Mater Res Part A 2013:101A:1302–1310.
Mechanisms of antiproliferative drug release from bioresorbable porous structures†
Version of Record online: 15 OCT 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 101A, Issue 5, pages 1302–1310, May 2013
How to Cite
Kraitzer, A., Alperstein, D., Kloog, Y. and Zilberman, M. (2013), Mechanisms of antiproliferative drug release from bioresorbable porous structures. J. Biomed. Mater. Res., 101A: 1302–1310. doi: 10.1002/jbm.a.34436
- Issue online: 25 MAR 2013
- Version of Record online: 15 OCT 2012
- Manuscript Accepted: 31 AUG 2012
- Manuscript Revised: 26 JUL 2012
- Manuscript Received: 29 APR 2012
- Israel Science Foundation (ISF). Grant Number: 1312/07
- Slezak Foundation, Tel-Aviv University
- farnesylthiosalicilate (FTS);
- drug-eluting stents;
- local cancer treatment
Restenosis (renarrowing of the blood vessel wall) and cancer are two different pathologies that have drawn extensive research attention over the years. Antiproliferative drugs such as paclitaxel inhibit cell proliferation and are therefore effective in the treatment of cancer as well as neointimal hyperplasia, which is known to be the main cause of restenosis. Antiproliferative drugs are highly hydrophobic and their release from porous biodegradable structures is therefore advantageous. The release profiles of four antiproliferative drugs from highly porous polymeric structures were studied in this study in light of the physical properties of both the host polymers and the drug molecules, and a qualitative model was developed. The chemical structure of the polymer chain directly affects the drug release profile through water uptake in the early stages or degradation and erosion in later stages. It also affects the release profile indirectly, through the polymer's 3D porous structure. However, this effect is minor. The drug volume and molecular area dominantly affect its diffusion rate from the 3D porous structure and the drug's solubility parameter compared with that of the host polymer has some effect on the drug release profile. This model can also be used to describe release mechanisms of other hydrophobic drugs from porous structures. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.