How to cite this article: Overstreet DJ, Huynh R, Jarbo K, McLemore RY, Vernon BL. 2013. In situ forming, resorbable graft copolymer hydrogels providing controlled drug release. J Biomed Mater Res Part A 2013:101A:1437–1446.
In situ forming, resorbable graft copolymer hydrogels providing controlled drug release†
Article first published online: 31 OCT 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 101A, Issue 5, pages 1437–1446, May 2013
How to Cite
Overstreet, D. J., Huynh, R., Jarbo, K., McLemore, R. Y. and Vernon, B. L. (2013), In situ forming, resorbable graft copolymer hydrogels providing controlled drug release. J. Biomed. Mater. Res., 101A: 1437–1446. doi: 10.1002/jbm.a.34443
- Issue published online: 25 MAR 2013
- Article first published online: 31 OCT 2012
- Manuscript Accepted: 28 AUG 2012
- Manuscript Revised: 30 JUL 2012
- Manuscript Received: 26 APR 2012
- National Science Foundation GK-12 Down to Earth Science Graduate Fellowship
- controlled release;
- graft copolymer;
In situ forming hydrogels are promising drug delivery vehicles due to their ease of delivery as liquids and their ability to be used in sites with irregular geometries. In this work, we report on in situ forming, resorbable hydrogels based on N-isopropylacrylamide (NIPAAm) as a fluid-like controlled release gel. These gels are the first resorbable NIPAAm-based gels providing controlled release without relying on affinity between the drug and device. Therefore, these gels provide a more flexible delivery system which can be used to deliver any drug at a controlled rate. The polymers contain repeat units of NIPAAm with (R)-α-Acryloyloxy-β,β-dimethyl-γ-butyrolactone (DBLA) and varying amounts of hydrophilic Jeffamine® M-1000 acrylamide (JAAm) grafts. The graft copolymer architecture allows the water content of the hydrogels to be tuned over a wide range while keeping the initial gelation temperature below body temperature. Incorporation of JAAm in the polymers led to greater water content, faster gel degradation, and reduced burst release. Sustained release of the antimicrobial drugs cefazolin and vancomycin (over about 5 and 7 days, respectively) was observed from gels containing an intermediate amount of grafts which combined reduced phase separation with a degradation time of 40 days. The degradation byproducts of one hydrogel formulation were cytocompatible to NIH 3T3 fibroblasts at concentrations up to 2.5 wt %. This class of terpolymer hydrogels is a promising local delivery system for a wide variety of drugs, particularly for applications involving irregular geometries such as implant interfaces. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.