How to cite this article: Kim J, Hong J-W, Baek S. 2013. Longitudinal differences in the mechanical properties of the thoracic aorta depend on circumferential regions. J Biomed Mater Res Part A 2013:101A:1525–1529.
Longitudinal differences in the mechanical properties of the thoracic aorta depend on circumferential regions†
Article first published online: 5 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 101A, Issue 5, pages 1525–1529, May 2013
How to Cite
Kim, J., Hong, J.-W. and Baek, S. (2013), Longitudinal differences in the mechanical properties of the thoracic aorta depend on circumferential regions. J. Biomed. Mater. Res., 101A: 1525–1529. doi: 10.1002/jbm.a.34445
- Issue published online: 25 MAR 2013
- Article first published online: 5 NOV 2012
- Manuscript Accepted: 7 SEP 2012
- Manuscript Revised: 6 SEP 2012
- Manuscript Received: 12 MAR 2012
- National Science Foundation. Grant Number: CMMI-1150376
- Air Force Office of Scientific Research. Grant Number: FA 9550-10-1-0222
- vascular stiffness;
- aortic dissection;
- stent design
Understanding the mechanical behavior of the arterial wall and its spatial variations is essential for the study of vascular physiopathology and the design of biomedical devices that interact with the arterial wall. Although it is generally accepted that the aortic wall gets stiffer along its length, the spatial variations in the mechanical behavior of the thoracic aorta are not well understood. In this study, therefore, we investigate both longitudinal and circumferential variations in the mechanical properties of the porcine descending thoracic aorta. Using a previously developed experimental method and stress–strain analysis, the stress, stretch, tangent modulus (TM), and pressure–strain elastic modulus (PSEM) are estimated in the range of in vivo pressure. The results show that the longitudinal differences of both TM and PSEM are statistically significant in the posterior region but not in the anterior region. Both moduli are greater in the posterior distal region when compared with the other test regions. The findings of this study meet a need for clarifying the region investigated, especially in circumferential region, to study the regional variations in biomechanics of blood vessels. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.