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Bioactivity and hemocompatibility study of amorphous hydrogenated carbon coatings produced by pulsed magnetron discharge

Authors

  • C. Lopez-Santos,

    Corresponding author
    1. Namur Research Institute for Life Sciences (NARILIS), Research Centre for the Physics of Matter and Radiation (PMR), University of Namur (FUNDP), Rue de Bruxelles, 61, B-5000 Namur, Belgium
    • Namur Research Institute for Life Sciences (NARILIS), Research Centre for the Physics of Matter and Radiation (PMR), University of Namur (FUNDP), Rue de Bruxelles, 61, B-5000 Namur, Belgium
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  • J. L. Colaux,

    1. Namur Research Institute for Life Sciences (NARILIS), Research Centre for the Physics of Matter and Radiation (PMR), University of Namur (FUNDP), Rue de Bruxelles, 61, B-5000 Namur, Belgium
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  • J. Laloy,

    1. Namur Research Institute for Life Sciences (NARILIS), Namur Thrombosis and Hemostasis Center (NTHC), Department of Pharmacy, University of Namur (FUNDP), Namur, Belgium
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  • M. Fransolet,

    1. Namur Research Institute for Life Sciences (NARILIS), Research Unit on Cell Biology (URBC), University of Namur (FUNDP) Rue de Bruxelles, 61, B-5000 Namur, Belgium
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  • F. Mullier,

    1. Namur Research Institute for Life Sciences (NARILIS), Namur Thrombosis and Hemostasis Center (NTHC), Department of Pharmacy, University of Namur (FUNDP), Namur, Belgium
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  • C. Michiels,

    1. Namur Research Institute for Life Sciences (NARILIS), Research Unit on Cell Biology (URBC), University of Namur (FUNDP) Rue de Bruxelles, 61, B-5000 Namur, Belgium
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  • J.-M. Dogné,

    1. Namur Research Institute for Life Sciences (NARILIS), Namur Thrombosis and Hemostasis Center (NTHC), Department of Pharmacy, University of Namur (FUNDP), Namur, Belgium
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  • S. Lucas

    1. Namur Research Institute for Life Sciences (NARILIS), Research Centre for the Physics of Matter and Radiation (PMR), University of Namur (FUNDP), Rue de Bruxelles, 61, B-5000 Namur, Belgium
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  • How to cite this article: Lopez-Santos C, Colaux JL, Laloy J, Fransolet M, Mullier F, Michiels C, Dogné J-M, Lucas S. 2013. Bioactivity and hemocompatibility study of amorphous hydrogenated carbon coatings produced by pulsed magnetron discharge. J Biomed Mater Res Part A 2013:101A:1800–1812.

Abstract

Literature contains very few data about the potential biomedical application of amorphous hydrogenated carbon (a-C:H) thin films deposited by reactive pulsed magnetron discharge even so it is one of the most scalable plasma deposition technique. In this article, we show that such a C2H2 pulsed magnetron plasma produces high quality coating with good hemocompatibility and bioactive response: no effect on hemolysis and hemostasis were observed, and proliferation of various cell types such as endothelial, fibroblast, and osteoblast-like cells was not affected when the deposition conditions were varied. Cell growth on a-C:H coatings is proposed to take place by a two-step process: the initial cell contact is affected by the smooth topography of the a-C:H coatings, whereas the polymeric-like structure, together with a moderate hydrophilicity and a high hydrogen content, directs the posterior cell spreading while preserving the hemocompatible behavior. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

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