Degradable magnesium-based implant materials with anti-inflammatory activity

Authors

  • Qiuming Peng,

    Corresponding author
    1. State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, People's Republic of China
    • State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, People's Republic of China
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  • Kun Li,

    1. State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, People's Republic of China
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  • Zengsheng Han,

    1. State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, People's Republic of China
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  • Erde Wang,

    1. School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, People's Republic of China
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  • Zhigang Xu,

    1. NSF Engineering Research Center for Revolutionizing Metallic Biomaterials, Suite #105, Fort IRC Building, 1601 East Market Street, North Carolina
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  • Riping Liu,

    1. State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, People's Republic of China
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  • Yongjun Tian

    1. State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, People's Republic of China
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  • How to cite this article: Peng Q, Li K, Han Z, Wang E, Xu Z, Liu R, Tian Y. 2013. Degradable magnesium-based implant materials with anti-inflammatory activity. J Biomed Mater Res Part A 2013:101A:1898–1906.

Abstract

The objective of this study was to prepare a new biodegradable Mg-based biomaterial, which provides good mechanical integrity in combination with anti-inflammatory function during the degradation process. The silver element was used, because it improved the mechanical properties as an effective grain refiner and it is also treated as a potential anti-inflammatory core. The new degradable Mg-Zn-Ag biomaterial was prepared by zone solidification technology and extrusion. The mechanical properties were mostly enhanced by fine grain strengthening. In addition, the alloys exhibited good cytocompatibility. The anti-inflammatory function of degradation products was identified by both interleukin-1α and nitric oxide modes. The anti-inflammatory impact was significantly associated with the concentration of silver ion. It was demonstrated that Mg-Zn-Ag system was a potential metallic stent with anti-inflammatory function, which can reduce the long-term dependence of anti-inflammatory drug after coronary stent implantation. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

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