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Cytocompatibility and osteogenic activity of a novel calcium phosphate silicate bioceramic: Silicocarnotite

Authors

  • Wei Duan,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People's Republic of China
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  • Congqin Ning,

    Corresponding author
    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People's Republic of China
    • State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People's Republic of China
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  • Tingting Tang

    Corresponding author
    1. Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, People's Republic of China
    • Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, People's Republic of China
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  • How to cite this article: Duan W, Ning C, Tang T. 2013. Cytocompatibility and osteogenic activity of a novel calcium phosphate silicate bioceramic: Silicocarnotite. J Biomed Mater Res Part A 2013:101A:1955–1961.

Abstract

In the present study, the effect of a novel bioceramic, silicon-containing calcium phosphate ceramic (silicocarnotite, Ca5(PO4)2SiO4, CPS) on attachment, proliferation, and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBMSC) has been investigated in comparison to hydroxyapatite (HA). The CPS showed a similar cell attachment behavior to HA, while the proliferation of rBMSC on CPS was significantly higher than that on HA, which indicated that CPS had a good cytocompatibility. Moreover, the expression of alkaline phosphatase activity and osteogenic-related genes, including Runx-2, osteopontin (OPN), bone sialoprotein (BSP) and osteocalcin (OC), demonstrated that CPS enhanced the osteogenic differentiation of rBMSC and accelerated the differentiation process. The results suggest that CPS ceramic exhibits a good cytocompatibility and osteogenic activity, which might be used as a potential candidate material for bone tissue engineering. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

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