How to cite this article: Nikom J, Charoonpatrapong-Panyayong K, Kedjarune-Leggat U, Stevens R, Kosachan N, Jaroenworaluck A. 2013. 3D interconnected porous HA scaffolds with SiO2 additions: Effect of SiO2 content and macropore size on the viability of human osteoblast cells. J Biomed Mater Res Part A 2013:101A:2295–2305.
3D interconnected porous HA scaffolds with SiO2 additions: Effect of SiO2 content and macropore size on the viability of human osteoblast cells†
Article first published online: 27 JAN 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 101A, Issue 8, pages 2295–2305, August 2013
How to Cite
Nikom, J., Charoonpatrapong-Panyayong, K., Kedjarune-Leggat, U., Stevens, R., Kosachan, N. and Jaroenworaluck, A. (2013), 3D interconnected porous HA scaffolds with SiO2 additions: Effect of SiO2 content and macropore size on the viability of human osteoblast cells. J. Biomed. Mater. Res., 101A: 2295–2305. doi: 10.1002/jbm.a.34523
- Issue published online: 23 JUN 2013
- Article first published online: 27 JAN 2013
- Manuscript Accepted: 6 NOV 2012
- Manuscript Revised: 3 NOV 2012
- Manuscript Received: 24 APR 2012
- National Metal and Materials Technology Center (MTEC). Grant Number: MT-B-52-CER-07-238-I
- HA-SiO2 scaffolds;
- 3D interconnected macropores;
- human osteoblast cell viability
3D interconnected porous scaffolds of HA and HA with various additions of SiO2 were fabricated using a polymeric template technique, to make bioceramic scaffolds consisting of macrostructures of the interconnected macropores. Three different sizes of the polyurethane template were used in the fabrication process to form different size interconnected macropores, to study the effect of pore size on human osteoblast cell viability. The template used allowed fabrication of scaffolds with pore sizes of 45, 60, and 75 ppi, respectively. Scanning microscopy was used extensively to observe the microstructure of the sintered samples and the characteristics of cells growing on the HA surfaces of the interconnected macropores. It has been clearly demonstrated that the SiO2 addition has influenced both the phase transformation of HA to TCP (β-TCP and α-TCP) and also affected the human osteoblast cell viability grown on these scaffolds. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.