How to cite this article: Amiri A, Memarpoor-Yazdi M, Shanbedi M, Eshghi H. 2013. Influence of different amino acid groups on the free radical scavenging capability of multi walled carbon nanotubes. J Biomed Mater Res Part A 2013:101A:2219–2228.
Influence of different amino acid groups on the free radical scavenging capability of multi walled carbon nanotubes †
Article first published online: 28 DEC 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 101A, Issue 8, pages 2219–2228, August 2013
How to Cite
Amiri, A., Memarpoor-Yazdi, M., Shanbedi, M. and Eshghi, H. (2013), Influence of different amino acid groups on the free radical scavenging capability of multi walled carbon nanotubes . J. Biomed. Mater. Res., 101A: 2219–2228. doi: 10.1002/jbm.a.34527
- Issue published online: 23 JUN 2013
- Article first published online: 28 DEC 2012
- Manuscript Accepted: 13 NOV 2012
- Manuscript Revised: 8 NOV 2012
- Manuscript Received: 29 SEP 2012
- Iranian Nano Technology Initiative
- antioxidant activity;
- amino acids;
- radical scavenging
Multi-walled carbon nanotubes (MWCNTs) were functionalized with a series of amino acids (lysine, arginine, cysteine, histidine, and aspartic acid) by sonication. Surface functional groups of the treated MWCNTs were investigated by infrared spectroscopy, Raman spectroscopy and thermogravimetric analysis. The results indicated the formation of various amino acid functionalities on the MWCNT surface, as well as the improved dispersion of MWCNTs in water. After functionalization, the antioxidant activity of all treated samples was analyzed using 2,2-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH), and hydroxyl radical scavenging, metal ion chelating, and reducing power assays. The antioxidant activity of the functionalized MWCNTs was 2–2.5 times greater than that of reduced glutathione (GSH) in ABTS radical scavenging, 1.5–5 times greater than that of GSH in reducing power, 1.3–1.8 times greater than that of butylated hydroxyanisole (BHA) in DPPH scavenging, and 3–10 times greater than that of GSH in hydroxyl radical scavenging. Accordingly, the amino acid-functionalized MWCNTs were appeared to be more potent than BHA and GSH synthetic antioxidants, and can thus be considered as excellent antioxidants to scavenge free radicals. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.