Functional nanofiber mat of polyvinyl alcohol/gelatin containing nanoparticles of biphasic calcium phosphate for bone regeneration in rat calvaria defects

Authors

  • Nguyen Thuy Ba Linh,

    1. Department of Biomedical Eng. & Mater., College of Medicine, Soonchunhyang University, 366-1 Ssangyong dong, Cheonan, 330-090, South Korea
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  • Kap-Ho Lee,

    1. Department of Nanomaterials Engineering, College of Engineering, Chungnam National University, Yuseong-Gu, Daejon 305, South Korea
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  • Byong-Taek Lee

    Corresponding author
    1. Department of Biomedical Eng. & Mater., College of Medicine, Soonchunhyang University, 366-1 Ssangyong dong, Cheonan, 330-090, South Korea
    2. Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, 366-1 Ssangyong Dong, Cheonan, 330-090, South Korea
    • Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University, 366-1 Ssangyong Dong, Cheonan, 330-090, South Korea
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  • How to cite this article: Linh NTB, Lee K-H, Lee B-T. 2013. Functional nanofiber mat of polyvinyl alcohol/gelatin containing nanoparticles of biphasic calcium phosphate for bone regeneration in rat calvaria defects. J Biomed Mater Res Part A 2013:101A:2412–2423.

Abstract

New biodegradable mats was successfully obtained by functional polyvinyl alcohol (PVA)/Gelatin (GE) blend fiber mats containing different BCP amounts (20, 40, and 50 w/v%) of biphasic calcium phosphate (BCP) nanoparticles for bone regeneration. BCP nanoparticles were loaded and dispersed successfully in the PVA/GE fibrous matrix. The addition of BCP was found to have increased fiber diameter, tensile strength, osteoblast cell adhesion, proliferation, and protein expression. Compared to the others, the 50% BCP-loaded electrospun PVA/GE fibers had the most favorable mechanical properties, cell attachment and growth, and protein expression. In vivo bone formation was examined using rat models, and increased bone formation was observed for the 50% BCP-loaded electrospun PVA/GE blends within 2 and 4 weeks. This result suggests that the 50% BCP-PVA/GE composite nanofiber mat has high potential for use in the field of bone regeneration and tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

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