Sr, Mg cosubstituted HA porous macro-granules: Potentialities as resorbable bone filler with antiosteoporotic functions
Article first published online: 24 JAN 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 101A, Issue 9, pages 2481–2490, September 2013
How to Cite
How to cite this article: 2013. Sr, Mg cosubstituted HA porous macro-granules: Potentialities as resorbable bone filler with antiosteoporotic functions. J Biomed Mater Res Part A 2013:101A:2481–2490., , , .
- Issue published online: 22 JUL 2013
- Article first published online: 24 JAN 2013
- Manuscript Accepted: 4 DEC 2012
- Manuscript Revised: 31 OCT 2012
- Manuscript Received: 1 AUG 2012
- strontium magnesium cosubstituted apatite;
- porous macro-granules;
- ion release;
- in vitro test;
- osteoblast behavior
Porous macro-granules of nanostructured apatite with Ca ions partially cosubstituted with Mg and Sr ions in different ratios (SrMgHAs), were synthesized at 37°C and compared with Mg and/or Sr free apatites (MgHAs and HA). Strontium improved the Mg substitution extent in the apatite and the chemical-physical and thermal stability of the resulting cosubstituted apatite. Porous macro-granules of 400–600 micron with selected composition were tested for the ionic release in synthetic body fluid and the data were related with the results of preliminary cell investigation in vitro. As compared to the corresponding Sr-free granulate, the SrMgHA could be exploited to prolong the beneficial Mg release during the bone regeneration process. In addition the contemporary in situ supply of Sr, an antiosteoporotic and anticarie ion, could influence the quality of new hard tissues. The ionic multirelease created a more favorable environment for human osteoblasts, demonstrated by a proliferative effect for each dose tested in the range 0.1–10 mg/mL. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 2481–2490, 2013.