In vitro and in vivo mechanical properties of human ulnar and median nerves
Version of Record online: 9 APR 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 101A, Issue 9, pages 2718–2725, September 2013
How to Cite
How to cite this article: 2013. In vitro and in vivo mechanical properties of human ulnar and median nerves. J Biomed Mater Res Part A 2013:101A:2718–2725., , , , , .
- Issue online: 22 JUL 2013
- Version of Record online: 9 APR 2013
- Manuscript Accepted: 17 DEC 2012
- Manuscript Revised: 12 DEC 2012
- Manuscript Received: 15 SEP 2012
- Austin BioInnovation Institute in Akron (ABIA)
- peripheral nerve;
- mechanical properties;
- finite element methods;
Peripheral nerves are often subjected to mechanical stretching, which in excess results in various degrees of impairment of their function. An understanding of the biomechanical behavior of peripheral nerves is important to the prevention of nerve injury during surgical manipulation. Here, in vitro mechanical properties and viscoelastic behavior of human ulnar/median nerves were measured with a tensile tester. In vivo stress and deformation of an ulnar nerve was also examined in continuity during a surgical procedure. Finite element models were developed to determine in vitro and in vivo viscoelastic parameters of the nerves. The results show that in vitro mechanical properties of fresh ulnar nerve are different from those measured in vivo. Several factors that are possibly attributed to the difference were analyzed. The in situ strain of the nerves is one of the major factors that must be considered to obtain accurate strain–stress relationship in the in vivo measurement. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 2718–2725, 2013.