New hydrogel obtained from a novel dendritic monomer as a promising candidate for biomedical applications

Authors

  • Julio César Cuggino,

    1. Departamento de Química Orgánica, IMBIV-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina
    Search for more papers by this author
  • Germán Charles,

    1. Departamento de Química Orgánica, IMBIV-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina
    Search for more papers by this author
  • Gerardo Gatti,

    1. Departamento de Bioquímica Clínica, CIBICI-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina
    2. Fundación para el Progreso de la Medicina—Laboratorio de Alta Complejidad, Córdoba 5000, Argentina
    Search for more papers by this author
  • Miriam Cristina Strumia,

    1. Departamento de Química Orgánica, IMBIV-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina
    Search for more papers by this author
  • Cecilia Inés Alvarez Igarzabal

    Corresponding author
    1. Departamento de Química Orgánica, IMBIV-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina
    Search for more papers by this author

Abstract

Acid functional hydrogels are a type of materials with many advantages. Over the last years, increasing attention for the synthesis of dendronized polymers has been drawn due to their unique properties of high multivalence in the same surface as compared with conventional polymers. In this study, we report the preparation of novel acid dendronized hydrogels using a dendritic monomer obtained from Behera's amine. The swelling and rheological performance, the non-toxicity over fibroblast cells and the drug encapsulation capacity of the novel hydrogels suggests that the new materials can achieve great potential as carrier for drug delivery and other potential biomedical applications. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3372–3381, 2013.

Ancillary