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Modeling the microstructurally dependent mechanical properties of poly(ester-urethane-urea)s

Authors

  • P. Daniel Warren,

    1. Graduate Interdisciplinary Program in Biomedical Engineering, The University of Arizona, Tucson, Arizona 85721-0119
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  • Dalton G. Sycks,

    1. Department of Materials Science, The University of Arizona, Tucson, Arizona 85721-0119
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  • Dominic V. McGrath,

    1. Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona 85721-0119
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  • Jonathan P. Vande Geest

    Corresponding author
    1. Graduate Interdisciplinary Program in Biomedical Engineering, The University of Arizona, Tucson, Arizona 85721-0119
    2. Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, Arizona 85721-0119
    3. Department of Biomedical Engineering, The University of Arizona, Tucson, Arizona 85721-0119
    4. BIO5 Institute, The University of Arizona, Tucson, Arizona 85721-0119
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Abstract

Poly(ester-urethane-urea) (PEUU) is one of many synthetic biodegradable elastomers under scrutiny for biomedical and soft tissue applications. The goal of this study was to investigate the effect of the experimental parameters on mechanical properties of PEUUs following exposure to different degrading environments, similar to that of the human body, using linear regression, producing one predictive model. The model utilizes two independent variables of poly(caprolactone) (PCL) type and copolymer crystallinity to predict the dependent variable of maximum tangential modulus (MTM). Results indicate that comparisons between PCLs at different degradation states are statistically different (p < 0.0003), while the difference between experimental and predicted average MTM is statistically negligible (p < 0.02). The linear correlation between experimental and predicted MTM values is R2 = 0.75. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3382–3387, 2013.

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