Surface modification of implanted cardiovascular metal stents: From antithrombosis and antirestenosis to endothelialization
Article first published online: 24 AUG 2013
© 2013 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 102, Issue 2, pages 588–609, February 2014
How to Cite
How to cite this article: Surface modification of implanted cardiovascular metal stents: From antithrombosis and antirestenosis to endothelialization. J Biomed Mater Res Part A 2014:102A:588–609., , , , , . 2014.
- Issue published online: 14 DEC 2013
- Article first published online: 24 AUG 2013
- Accepted manuscript online: 21 MAR 2013 04:15AM EST
- Manuscript Accepted: 11 MAR 2013
- Manuscript Revised: 8 MAR 2013
- Manuscript Received: 17 NOV 2012
- Key Basic Research Project. Grant Number: 2011CB606204
- National Natural Science Foundation of China. Grant Number: 31170916#
- Fundamental Research Funds for the Central Universities. Grant Number: SWJTU11ZT11
- surface modification;
- metal stents;
- in-stent restenosis;
Driven by the complications occurring with bare metal stents and drug-eluting stents, concerns have been raised over strategies for long-term safety, with respect to preventing or inhibiting stent thrombosis, restenosis, and in-stent restenosis in particularly. Surface modification is very important in constructing a buffer layer at the interface of the organic and inorganic materials and in ultimately obtaining long-term biocompatibility. In this review, we summarize the developments in surface modification of implanted cardiovascular metal stents. This review focuses on the modification of metal stents via coating drugs or biomolecules to enhance antithrombosis, antirestenosis, and/or endothelialization. In addition, we indicate the probable future work involving the modification of the metallic blood-contacting surfaces of stents and other cardiovascular devices that are under development. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 588–609, 2014.