A biodegradable thermoset polymer made by esterification of citric acid and glycerol
Article first published online: 24 JUN 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 102, Issue 5, pages 1467–1477, May 2014
How to Cite
How to cite this article: 2014. A biodegradable thermoset polymer made by esterification of citric acid and glycerol. J Biomed Mater Res Part A 2014: 102A:1467–1477., , , , , .
- Issue published online: 24 MAR 2014
- Article first published online: 24 JUN 2013
- Accepted manuscript online: 4 JUN 2013 12:00AM EST
- Manuscript Accepted: 22 MAY 2013
- Manuscript Revised: 21 MAY 2013
- Manuscript Received: 15 FEB 2013
- National Institutes of Health Ruth L. Kirschstein National Research Service Award. Grant Number: T32 AR007505
- controlled drug release;
- citric acid;
- degradable polymers
A new biomaterial, a degradable thermoset polymer, was made from simple, economical, biocompatable monomers without the need for a catalyst. Glycerol and citric acid, nontoxic and renewable reagents, were crosslinked by a melt polymerization reaction at temperatures from 90 to 150°C. Consistent with a condensation reaction, water was determined to be the primary byproduct. The amount of crosslinking was controlled by the reaction conditions, including temperature, reaction time, and ratio between glycerol and citric acid. Also, the amount of crosslinking was inversely proportional to the rate of degradation. As a proof-of-principle for drug delivery applications, gentamicin, an antibiotic, was incorporated into the polymer with preliminary evaluations of antimicrobial activity. The polymers incorporating gentamicin had significantly better bacteria clearing of Staphylococcus aureus compared to non-gentamicin gels for up to 9 days. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1467–1477, 2014.