Biomimetic composites by surface-initiated polymerization of cyclic lactones at anorganic bone: Preparation and in vitro evaluation of osteoblast and osteoclast competence
Article first published online: 28 JUN 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 102, Issue 6, pages 1755–1766, June 2014
How to Cite
How to cite this article: 2014. Biomimetic composites by surface-initiated polymerization of cyclic lactones at anorganic bone: Preparation and in vitro evaluation of osteoblast and osteoclast competence. J Biomed Mater Res Part A 2014;102A:1755–1766., , , , , , , , .
- Issue published online: 18 APR 2014
- Article first published online: 28 JUN 2013
- Accepted manuscript online: 15 JUN 2013 04:27AM EST
- Manuscript Accepted: 6 JUN 2013
- Manuscript Revised: 30 APR 2013
- Manuscript Received: 9 FEB 2013
- USAMRMC Award. Grant Number: W81XWH-09-1-0745
- biomimetic material;
- bone graft;
- hydroxyapatite composite;
- anorganic bone;
Biomimetic composites were constructed using anorganic bone to initiate the polymerization of cyclic lactones. The resulting anorganic bone/polylactone composites preserve the inorganic structure and the mechanical properties of the original bone. Thermal conditions used to prepare the anorganic bone were shown to control the surface functionalities, surface area, and crystallinity, all of which influence the rates of subsequent polymerizations. Thermal pretreatment of anorganic bone was examined as a function of time and temperature, ranging from 400°C to 800°C. Polymerization rates of different monomers were also compared. Additionally, in vitro evaluations of anorganic bone/poly-l-lactide and anorganic bone/polyglycolide composites for osteoblast and osteoclast competence suggest that these composites are good candidates for potential in vivo use, since both composites promoted osteoblast differentiation. The anorganic bone/poly-l-lactide composite also promoted osteoclast differentiation. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1755–1766, 2014.