Both authors contributed equally to this work.
Elastic properties of human posterior eye
Article first published online: 17 AUG 2013
© 2013 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 102, Issue 6, pages 2001–2007, June 2014
How to Cite
How to cite this article: 2014. Elastic properties of human posterior eye. J Biomed Mater Res Part A 2014:102A:2001–2007., , , .
- Issue published online: 18 APR 2014
- Article first published online: 17 AUG 2013
- Accepted manuscript online: 12 JUL 2013 08:48PM EST
- Manuscript Accepted: 21 JUN 2013
- Manuscript Revised: 4 JUN 2013
- Manuscript Received: 31 MAR 2013
- Department of Energy's Office of Science. Grant Number: DE-FC02–04ER63735
- W.M. Keck Foundation, Clarence and Estelle Albaugh Trust
- human retina;
- choroid and sclera;
- mechanical properties;
- uniaxial test;
This study examines the elastic properties of the human posterior retina, choroid, and sclera. Twenty-four human eyes from 30- to 74-year-old donors were obtained from an eye bank. Vertically and horizontally oriented tissue strips of the retina, choroid, and sclera (ideally n = 12 in each group) were harvested from the posterior eyes. Their thicknesses were estimated optically. The samples were stretched at 1 mm/s in 37°C saline. Stress and strain were obtained from the mechanical tests, and then the transition stress, transition strain, toe modulus, and heel modulus were calculated. Statistical analysis was performed for comparison between groups. Linear regression analyses were used to explore the relationship between the mechanical parameters and age. We found that the stress–strain relationship of the retina, choroid, and sclera were nonlinear. Except for the retinal transition strain (p = 0.0124), no statistical difference was found between the vertical and horizontal meridian in the mechanical parameters (p > 0.05). Furthermore, weak relationship was observed between some of the mechanical parameters and the donors' age. Our results suggest that there is significant anisotropy in the retina, and mechanical properties of each layer may change with age. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2001–2007, 2014.