New sol-gel bioactive glass and titania composites with enhanced physico-chemical and biological properties
Article first published online: 12 SEP 2013
© 2013 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 102, Issue 7, pages 2383–2394, July 2014
How to Cite
How to cite this article: 2014. New sol-gel bioactive glass and titania composites with enhanced physico-chemical and biological properties. J Biomed Mater Res Part A 2014: 102A: 2383–2394., , , , .
- Issue published online: 23 MAY 2014
- Article first published online: 12 SEP 2013
- Accepted manuscript online: 31 JUL 2013 04:01AM EST
- Manuscript Accepted: 24 JUL 2013
- Manuscript Revised: 26 MAY 2013
- Manuscript Received: 18 MAR 2013
- Polish Ministry for Science and Education (M.L.). Grant Number: NN508 476338
- National Science Center (A.M.O.). Grant Number: B\NZ4\00664
- University of Science and Technology (M.L., K.C.K., J.P.). Grant Number: 184.108.40.2065
- sol-gel bioactive glass;
- titanium dioxide;
- compressive strength;
- human bone marrow stromal cells
We developed TiO2 matrix composites modified by sol-gel bioactive glasses (SBG) of either high CaO content (A2) or high SiO2 content (S2). The latter were mixed with titanium dioxide (TiO2) at 75:25, 50:50, and 25:75 weight ratios and sintered at 1250°C for 2 h. We examined the effects of various types (A2 or S2) and compositional TiO2:SBG ratios on the mechanical properties of resulting composites, their bioactivity and human bone marrow mesenchymal stem cells (MSC) response. The chemistry of SBGs influenced the phase composition, mechanical and biological properties of the composites. Rutile and titanite prevailed in A2-TiO2 composites, and rutile and crystobalite in S2-TiO2 composites. Compressive strength increased significantly for 25A2-TiO2 composites (140 MPa) compared to matrix TiO2 (58 MPa). Composites containing 50–75 wt % of either SBG displayed bioactive properties as determined by simulated body fluid test. Compared to TiO2, human bone marrow stromal cell (BMSC) viability was enhanced on the composites containing 25 wt % of either SBG, whereas the composites modified by 25 wt % of S2 enhanced alkaline phosphatase activity and mineralization in cultures treated with osteogenic inducers–dexamethasone (Dex) or bone morphogenetic protein. Increasing amounts of A2 in TiO2 matrix decreased cell viability but increased collagen deposition and mineralized matrix production by BMSC. Considering the physico-chemical and biological properties of the presented composites, the modification of TiO2 with SBG may prove useful strategy in several bone tissue related regeneration strategies. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2383–2394, 2014.