Rates of in vivo (arterial) and in vitro biocorrosion for pure magnesium
Version of Record online: 3 APR 2014
© 2014 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 103, Issue 1, pages 341–349, January 2015
How to Cite
How to cite this article: 2015. Rates of in vivo (arterial) and in vitro biocorrosion for pure magnesium. J Biomed Mater Res Part A 2015:103A:341–349., , , .
- Issue online: 25 NOV 2014
- Version of Record online: 3 APR 2014
- Accepted manuscript online: 25 MAR 2014 12:40AM EST
- Manuscript Accepted: 21 MAR 2014
- Manuscript Revised: 6 MAR 2014
- Manuscript Received: 12 DEC 2013
- DeVlieg Foundation
- American Heart Association
- in vitro test;
- in vivo test
The development of magnesium-based materials for bioabsorbable stents relies heavily on corrosion testing by immersion in pseudophysiological solutions, where magnesium degrades faster than it does in vivo. The quantitative difference in corrosion kinetics in vitro and in vivo is largely unknown, but, if determined, would help reduce dependence on animal models. In order to create a quantitative in vitro–in vivo correlation based on an accepted measure of corrosion (penetration rate), commercially pure magnesium wires were corroded in vivo in the abdominal aortas of rats for 5−32 days, and in vitro for up to 14 days using Dulbecco's modified eagle medium. Cross-sectioning, scanning electron microscopy, image analysis, a modified penetration rate tailored to degraded wires, and empirical modeling were used to analyze the corroded specimens. In vitro penetration rates were consistently higher than comparable in vivo rates by a factor of 1.2−1.9× (±0.2×). For a sample <20% corroded, an approximate in vitro–in vivo multiplier of 1.3 ± 0.2× was applied, whereas a multiplier of 1.8 ± 0.2× became appropriate when the magnesium specimen was 25−35% degraded. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 341–349, 2015.