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Keywords:

  • collagen;
  • antigenicity;
  • immunogenicity;
  • clinical response;
  • atelocollagen;
  • pepsin treatment;
  • crosslinking;
  • collagen-induced autoimmunity

Abstract

Pertinent issues of collagen antigenicity and immunogenicity are concisely reviewed as they relate to the design and application of biomedical devices. A brief discussion of the fundamental concepts of collagen immunochemistry is presented, with a subsequent review of documented clinical responses to devices containing reconstituted soluble or solubilized collagen. The significance of atelocollagen, concerns regarding collagen-induced autoimmunity, and other relevant topics are also addressed in the context of current understanding of the human immune response to collagen. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 71B: 343–354, 2004