Antimicrobial activity and local release characteristics of chlorhexidine diacetate loaded within the dental copolymer matrix, ethylene vinyl acetate

Authors

  • Roland R. Arnold,

    1. Dental Research Center, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599–7450
    2. Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599–7450
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  • Hong Hong Wei,

    1. Dental Research Center, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599–7450
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  • Eric Simmons,

    1. Dental Research Center, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599–7450
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  • Padmavathy Tallury,

    1. Dental Research Center, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599–7450
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  • David A. Barrow,

    1. Dental Research Center, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599–7450
    2. Center for Oral and Systemic Diseases, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599–7450
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  • Sid Kalachandra

    Corresponding author
    1. Dental Research Center, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599–7450
    2. Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599–7450
    3. Center for Oral and Systemic Diseases, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599–7450
    • Dental Research Center, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599–7450
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Abstract

In vitro results are presented for a novel oral drug-delivery system ultimately intended for treatment of oral infections in immunocompromised patients. Test samples of ethylene vinyl acetate copolymer (EVA) containing chlorhexidine diacetate (CDA) showed desirable antimicrobial properties and steady, slow release into aqueous and other media after an initial burst of drug release in the first day of liquid exposure. By washing away this initial burst, the proposed mouthguard device should be capable of sustained delivery of locally effective CDA concentrations far below systemically toxic levels. A prolonged room temperature shelf-life of at least 1 year, and effectivity against a wide range of oral bacteria and Candida species was demonstrated. Drug loaded films showed a top-to-bottom asymmetry in drug release, but good lateral homogeneity, and a linear relationship between initial CDA loading concentration (from 0.63 to 10 wt %) and days 3–14 release rates in a static aqueous environment. The EVA matrix containing CDA appears to possess many suitable properties for localized oral delivery of sustained antimicrobial activity. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008

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