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Regeneration of ischemic heart using hyaluronic acid-based injectable hydrogel

Authors

  • So Jeong Yoon,

    1. Department of Biomedical Engineering, Biomedical Science of Brain Korea 21, Medical College, Korea University, Seoul, Korea
    2. Korea Artificial Organ Center, Korea University, Seoul, Korea
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    • So Jeong Yoon and Yang Hu Fang contributed equally to this work.

  • Yong Hu Fang,

    Corresponding author
    1. Department of Thoracic and Cardiovascular Surgery, Medical College, Korea University, Seoul, Korea
    • Department of Biomedical Engineering, Biomedical Science of Brain Korea 21, Medical College, Korea University, Seoul, Korea
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    • So Jeong Yoon and Yang Hu Fang contributed equally to this work.

  • Choon Hak Lim,

    1. Department of Anesthesiology and Pain Medicine, Medical College, Korea University, Seoul, Korea
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  • Bum Shik Kim,

    1. Department of Thoracic Surgery, Kyunghee University, Seoul, Korea
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  • Ho Sung Son,

    1. Korea Artificial Organ Center, Korea University, Seoul, Korea
    2. Department of Thoracic and Cardiovascular Surgery, Medical College, Korea University, Seoul, Korea
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  • Yongdoo Park,

    Corresponding author
    1. Department of Biomedical Engineering, Biomedical Science of Brain Korea 21, Medical College, Korea University, Seoul, Korea
    2. Korea Artificial Organ Center, Korea University, Seoul, Korea
    • Department of Biomedical Engineering, Biomedical Science of Brain Korea 21, Medical College, Korea University, Seoul, Korea
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  • Kyung Sun

    1. Department of Biomedical Engineering, Biomedical Science of Brain Korea 21, Medical College, Korea University, Seoul, Korea
    2. Korea Artificial Organ Center, Korea University, Seoul, Korea
    3. Department of Thoracic and Cardiovascular Surgery, Medical College, Korea University, Seoul, Korea
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Abstract

An injectable hydrogel was applied to regenerate a myocardial infarction and functional recovery of the heart. A myocardial infarction was induced in rat by circumflex artery ligation. A hyaluronic acid-based hydrogel was injected into the epicardium of the infarcted area. Then, cardiac functions and regeneration of the myocardium in sham-operated (SHAM), myocardial infarction (MI), and gel-injected group (GEL) (n = 6) were evaluated 4 weeks after the injection. Measurements of the thickness of the wall showed that the thickness in the GEL group increased by up to 200% compared with that in the MI group (p < 0.001). The infarcted area of the left ventricular in the GEL group decreased by 53% compared with the MI group (p < 0.001). The number of arterioles and capillaries in the border zone of the GEL group increased by 152% and 148%, whereas the apoptotic index decreased by 42% (p < 0.05). Measurement of the heart functions, such as ejection fraction, arterial elastance (Ea), dP/dt max, and dP/dt min, indicated that the injection of a hydrogel significantly facilitated the functional recovery compared with the MI group. Because of its simplicity, easy applicability, and a great regenerating potential, this injectable hydrogel promises as a treatment for myocardial infarction. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2009

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