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Metal ion-mediated nitric oxide generation from polyurethanes via covalently linked copper(II)-cyclen moieties
Article first published online: 13 MAY 2009
DOI: 10.1002/jbm.b.31391
Copyright © 2009 Wiley Periodicals, Inc.
Issue
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 91B, Issue 1, pages 203–212, October 2009
Additional Information
How to Cite
Puiu, S. C., Zhou, Z., White, C. C., Neubauer, L. J., Zhang, Z., Lange, L. E., Mansfield, J. A., Meyerhoff, M. E. and Reynolds, M. M. (2009), Metal ion-mediated nitric oxide generation from polyurethanes via covalently linked copper(II)-cyclen moieties. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 91B: 203–212. doi: 10.1002/jbm.b.31391
Publication History
- Issue published online: 27 AUG 2009
- Article first published online: 13 MAY 2009
- Manuscript Accepted: 2 MAR 2009
- Manuscript Revised: 11 FEB 2009
- Manuscript Received: 29 SEP 2008
Funded by
- NIH. Grant Numbers: EB000783, EB004527
- Abstract
- Article
- References
- Cited By
Keywords:
- polyurethane;
- nitric oxide;
- copper;
- hemocompatibility;
- catheter
Abstract
Polyurethanes are widely used in the manufacturing of biomedical catheters and other blood-contacting devices; however, thrombus formation still occurs, which renders these catheters ineffective unless systemic anticlotting agents are used. Nitric oxide (NO) is a well-known inhibitor of platelet activity. In the current study, two commercially available medical polyurethanes (Pellethane™ and Tecophilic®) were derivatized to possess NO-generating Cu(II)-cyclen moieties pendant to the polymer backbone. A new three-step synthetic approach is used, that is simpler than a recently reported method to prepare Cu(II)-cyclen-polyurethane materials. Both derivatized polyurethanes were found to produce NO at levels at or above those of endothelial cells. A comparison between the modified commercial polyurethanes (hydrophobic vs. hydrophilic) is presented, including the synthetic scheme, extensive characterization, and coating application. These derivatized polymers may serve as useful coatings to prevent clotting on the surface of catheters and other blood-contacting biomedical devices. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009