PEGylated silica nanoparticles encapsulating multiple magnetite nanocrystals for high-performance microscopic magnetic resonance angiography†

  1. Si-Han Wu1,‡,
  2. Chien-Yuan Lin2,‡,
  3. Yann Hung1,
  4. Wei Chen1,
  5. Chen Chang2,*,
  6. Chung-Yuan Mou1,*

Article first published online: 28 JUL 2011

DOI: 10.1002/jbm.b.31874

Issue

Journal of Biomedical Materials Research Part B: Applied Biomaterials

Journal of Biomedical Materials Research Part B: Applied Biomaterials

Volume 99B, Issue 1, pages 81–88, October 2011

Additional Information

How to Cite

Wu, S.-H., Lin, C.-Y., Hung, Y., Chen, W., Chang, C. and Mou, C.-Y. (2011), PEGylated silica nanoparticles encapsulating multiple magnetite nanocrystals for high-performance microscopic magnetic resonance angiography. J. Biomed. Mater. Res., 99B: 81–88. doi: 10.1002/jbm.b.31874

Author Information

  1. 1

    Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan

  2. 2

    Functional and Micro-Magnetic Resonance Imaging Center, Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan

  1. ‡

    These authors contributed equally to this work.

*Functional and Micro-Magnetic Resonance Imaging Center, Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan

  1. †

    How to cite this article: Wu S-H, Lin C-Y, Hung Y, Chen W, Chang C, Mou C-Y. 2011. PEGylated silica nanoparticles encapsulating multiple magnetite nanocrystals for high-performance microscopic magnetic resonance angiography. J Biomed Mater Res Part B 2011:99B:81–88.

Publication History

  1. Issue published online: 1 SEP 2011
  2. Article first published online: 28 JUL 2011
  3. Manuscript Accepted: 20 APR 2011
  4. Manuscript Revised: 30 MAR 2011
  5. Manuscript Received: 30 NOV 2010

Funded by

  • National Science Council of Taiwan. Grant Number: NSC 98-2120-M-002-002

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Keywords:

  • Fe3O4;
  • silica;
  • polyethylene glycol;
  • contrast agents;
  • MRI

Abstract

A novel magnetic resonance (MR) angiographic method, 3DΔR2-mMRA (three dimensional and ΔR2 based microscopy magnetic resonance angiography), is developed as a clinical diagnosis for depicting the function and structure of cerebral small vessels. However, the visibility of microvasculatures and the precision of cerebral blood volume calculation greatly rely on the transverse relaxivity and intravascular half-life of contrast agent, respectively. In this work, we report a blood pool contrast agent named H-Fe3O4@SiO2–PEG where multiple Fe3O4 nanocrystals are encapsulated in a thin silica shell to enhance the T2-relaxivity (r2 = 342.8 mM−1 s−1) and poly(ethylene glycol) (PEG) is employed to reduce opsonization and prolong circulation time of nanoparticles. Utilization of the newly developed H-Fe3O4@SiO2–PEG with a novel MR angiographic methodology, a high-resolution MR image of rat cerebral microvasculatures is successfully obtained. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.

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