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Keywords:

  • bioactive material;
  • biocompatibility/soft tissue;
  • bioresorbable;
  • blood-material interaction;
  • wound dressings

Abstract

In this work, we describe a novel technique for producing biocompatible medical products with bioactive properties from the biodegradable polymer dibutyrylchitin (DBC). Materials produced by blowing out polymer solutions have excellent hemostaic properties and are easy to handle during surgery. Biocompatibility studies, encompassing hemostasis and the evaluation of post-implantation reactions, indicate that the biological properties of DBC depend on the molecular mass of the polymer. Lower molecular mass polymers are preferable for use in implanted wound dressings. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.