How to cite this article: Huang D, Zuo Y, Zou Q, Wang Y, Gao S, Wang X, Liu H, Li Y. 2012. Reinforced nanohydroxyapatite/polyamide66 scaffolds by chitosan coating for bone tissue engineering. J Biomed Mater Res Part B 2012:100B:51-57.
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Reinforced nanohydroxyapatite/polyamide66 scaffolds by chitosan coating for bone tissue engineering†
Article first published online: 26 SEP 2011
DOI: 10.1002/jbm.b.31921
Copyright © 2011 Wiley Periodicals, Inc.
Issue
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 100B, Issue 1, pages 51–57, January 2012
Additional Information
How to Cite
Huang, D., Zuo, Y., Zou, Q., Wang, Y., Gao, S., Wang, X., Liu, H. and Li, Y. (2012), Reinforced nanohydroxyapatite/polyamide66 scaffolds by chitosan coating for bone tissue engineering. J. Biomed. Mater. Res., 100B: 51–57. doi: 10.1002/jbm.b.31921
- †
Publication History
- Issue published online: 6 DEC 2011
- Article first published online: 26 SEP 2011
- Manuscript Accepted: 16 JUN 2011
- Manuscript Received: 1 MAR 2011
Funded by
- China 973 funds. Grant Number: 2007CB936102
- China-Netherlands Programme Strategic Alliances. Grant Number: 2008DFB50120
- Abstract
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Keywords:
- reinforced scaffold;
- chitosan coating;
- nanohydroxyapatite/polyamide66 scaffold;
- high porosity;
- cytocompatibility
Abstract
High porosity of scaffold is always accompanied by poor mechanical property; the aim of this study was to enhance the strength and modulus of the highly porous scaffold of nanohydroxyapatite/polyamide66 (n-HA/PA66) by coating chitosan (CS) and to investigate the effect of CS content on the scaffold physical properties and cytological properties. The results show that CS coating can reinforce the scaffold effectively. The compress modulus and strength of the CS coated n-HA/PA66 scaffolds are improved to 32.71 and 2.38 MPa, respectively, being about six times and five times of those of the uncoated scaffolds. Meanwhile, the scaffolds still exhibit a highly interconnected porous structure and the porosity is approximate about 78%, slightly lower than the value (84%) of uncoated scaffold. The cytological properties of scaffolds were also studied in vitro by cocultured with osteoblast-like MG63 cells. The cytological experiments demonstrate that the reinforced scaffolds display favorable cytocompatibility and have no significant difference with the uncoated n-HA/PA66 scaffolds. The CS reinforced n-HA/PA66 scaffolds can meet the basic mechanical requirement of bone tissue engineering scaffold, presenting a potential for biomedical application in bone reconstruction and repair. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.