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Reinforced nanohydroxyapatite/polyamide66 scaffolds by chitosan coating for bone tissue engineering

Authors

  • Di Huang,

    1. Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, People's Republic of China
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  • Yi Zuo,

    Corresponding author
    1. Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, People's Republic of China
    • Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, People's Republic of China
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  • Qin Zou,

    1. Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, People's Republic of China
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  • Yanying Wang,

    1. Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, People's Republic of China
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  • Shibo Gao,

    1. Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, People's Republic of China
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  • Xiaoyan Wang,

    1. Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, People's Republic of China
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  • Haohuai Liu,

    1. Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, People's Republic of China
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  • Yubao Li

    Corresponding author
    1. Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, People's Republic of China
    • Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, People's Republic of China
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  • How to cite this article: Huang D, Zuo Y, Zou Q, Wang Y, Gao S, Wang X, Liu H, Li Y. 2012. Reinforced nanohydroxyapatite/polyamide66 scaffolds by chitosan coating for bone tissue engineering. J Biomed Mater Res Part B 2012:100B:51-57.

Abstract

High porosity of scaffold is always accompanied by poor mechanical property; the aim of this study was to enhance the strength and modulus of the highly porous scaffold of nanohydroxyapatite/polyamide66 (n-HA/PA66) by coating chitosan (CS) and to investigate the effect of CS content on the scaffold physical properties and cytological properties. The results show that CS coating can reinforce the scaffold effectively. The compress modulus and strength of the CS coated n-HA/PA66 scaffolds are improved to 32.71 and 2.38 MPa, respectively, being about six times and five times of those of the uncoated scaffolds. Meanwhile, the scaffolds still exhibit a highly interconnected porous structure and the porosity is approximate about 78%, slightly lower than the value (84%) of uncoated scaffold. The cytological properties of scaffolds were also studied in vitro by cocultured with osteoblast-like MG63 cells. The cytological experiments demonstrate that the reinforced scaffolds display favorable cytocompatibility and have no significant difference with the uncoated n-HA/PA66 scaffolds. The CS reinforced n-HA/PA66 scaffolds can meet the basic mechanical requirement of bone tissue engineering scaffold, presenting a potential for biomedical application in bone reconstruction and repair. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.

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