How to cite this article: Xia W, Lausmaa J, Thomsen P, Engqvist H. 2012. Highly packed and aligned fluoride substituted hydroxyapatite via a surfactant-free process. J Biomed Mater Res Part B 2012:100B:75-81.
Highly packed and aligned fluoride substituted hydroxyapatite via a surfactant-free process†
Article first published online: 27 SEP 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 100B, Issue 1, pages 75–81, January 2012
How to Cite
Xia, W., Lausmaa, J., Thomsen, P. and Engqvist, H. (2012), Highly packed and aligned fluoride substituted hydroxyapatite via a surfactant-free process. J. Biomed. Mater. Res., 100B: 75–81. doi: 10.1002/jbm.b.31924
- Issue published online: 6 DEC 2011
- Article first published online: 27 SEP 2011
- Manuscript Accepted: 23 MAY 2011
- Manuscript Revised: 8 MAY 2011
- Manuscript Received: 19 OCT 2010
- VINN Excellence Center of Biomaterials and Cell Therapy
- fluoride substituted hydroxyapatite;
- implant coating
Biomolecules and surfactants are believed to be the key factors for reconstruction of tooth enamel and preparation of fluoride hydroxyapatite coating with enamel-like structure on dental implants. We have developed an alternative surfactant-free biomimetic method to stimulate growth of fluoride substituted hydroxyapatite coatings with highly packed and aligned structure on metallic substrates. Oxidized titanium plates were chosen as the substrates. The biomimetic fluoride hydroxyapatite was prepared by immersing the pretreated Ti plates into the phosphate-buffered solution with Ca2+, H2PO4−, HPO42−, and F−. The pH value was controlled at 7.4 at the beginning. Every titanium plate (10 mm × 10 mm × 1 mm) was soaked into 20 mL of ion doped phosphate buffered solution in sealed plastic bottles, kept at 37°C or 60°C without stirring for time periods of 1 day to 2 weeks. After immersion, the samples were removed from the solution, rinsed with deionized water and allowed to dry in air. The fluoride substituted hydroxyapatite layer, composed of needle-like crystallites with the diameter of 10–20 nm, was well-organized and tightly packed. XRD results showed a sharper and stronger (002) peak, which could be used to explain that there was a preferable orientation along the c axis. The coating could be reconstructed on the former layer if the mineralization process was repeated, and the structure of the coating could be preserved. The method could be used to construct well organized fluoride substitute hydroxyapatite coating on metal implants. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.