How to cite this article: Weaver JD, Ku DN. 2012. Biomaterial testing for covered stent membranes: Evaluating thrombosis and restenosis potential. J Biomed Mater Res Part B 2012:100B:103-110.
Biomaterial testing for covered stent membranes: Evaluating thrombosis and restenosis potential†
Article first published online: 27 SEP 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 100B, Issue 1, pages 103–110, January 2012
How to Cite
Weaver, J. D. and Ku, D. N. (2012), Biomaterial testing for covered stent membranes: Evaluating thrombosis and restenosis potential. J. Biomed. Mater. Res., 100B: 103–110. doi: 10.1002/jbm.b.31927
- Issue published online: 6 DEC 2011
- Article first published online: 27 SEP 2011
- Manuscript Accepted: 7 JUL 2011
- Manuscript Revised: 16 MAR 2011
- Manuscript Received: 29 OCT 2010
- Carlos and Marguerite Mason Foundation
- L. P. Huang Chair Professorship
- covered stents;
- in vitro testing;
- polyvinyl alcohol cryogel
Covered stents may be able to prevent both thrombosis and restenosis, but new mechanically suitable and biocompatible materials are needed before this treatment option can become a reality. Hydrophilic polyvinyl alcohol (PVA) cryogels have desirable mechanical properties for covered stent membranes and may be able to provide a physical barrier to restenosis with low thrombogenicity. An in vitro flow loop with porcine blood was used to compare thrombus formation on different blood-contacting biomaterials. PVA cryogels were found to maintain blood flow with low thrombogenicity and were significantly less thrombogenic than polyester (p < 0.05). The ability to prevent hyperplasic in-growth was evaluated using a modified Boyden chamber cellular migration assay. PVA cryogel membranes used as a physical barrier were found to nearly eliminate cellular migration (p < 0.05) without cellular toxicity. Overall, this article demonstrates pivotal feasibility results for a covered stent membrane material that could prevent restenosis by means of a hydrogel barrier with low thrombogenicity. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.