How to cite this article: Smith MR, Atkinson P, White D, Piersma T, Gutierrez G, Rossini G, Desai S, Wellinghoff S, Yu H, Cheng X. 2012. Design and assessment of a wrapped cylindrical Ca-P AZ31 Mg alloy for critical-size ulna defect repair. J Biomed Mater Res Part B 2012:100B:206-216.
Design and assessment of a wrapped cylindrical Ca-P AZ31 Mg alloy for critical-size ulna defect repair†
Article first published online: 21 NOV 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 100B, Issue 1, pages 206–216, January 2012
How to Cite
Smith, M. R., Atkinson, P., White, D., Piersma, T., Gutierrez, G., Rossini, G., Desai, S., Wellinghoff, S., Yu, H. and Cheng, X. (2012), Design and assessment of a wrapped cylindrical Ca-P AZ31 Mg alloy for critical-size ulna defect repair. J. Biomed. Mater. Res., 100B: 206–216. doi: 10.1002/jbm.b.31940
- Issue published online: 6 DEC 2011
- Article first published online: 21 NOV 2011
- Manuscript Accepted: 25 JUN 2011
- Manuscript Revised: 1 JUN 2011
- Manuscript Received: 25 FEB 2011
- Southwest Research Institute Advisory Committee for Internal Research
- bone repair;
- in vivo test;
Recently, magnesium has been investigated as a promising bioresorbable orthopedic biomaterial. Its mechanical properties are very similar to natural bone, making it appropriate for load-bearing orthopedic fracture repair applications. However, significant hurdles remain regarding the design of practical implants and methods to control degradation and enhance biocompatibility. Although attempts have been made to hinder magnesium's rapid corrosion via alloying and coating, these studies have used solid monoliths. In an effort to reduce the amount of alloy used for implantation in a shape that mimics cortical bone shape, this study used a thin sheet of Mg AZ31 which was rolled into hollow cylindrical scaffolds. The scaffold was coated with different amounts of Ca-P; this implant demonstrated slowed corrosion in simulated body fluid (SBF) as well as enhanced biocompatibility for mesenchymal stem cells (MSC). In vivo implantation of magnesium alloy scaffold adjacent to the rat femur showed significant biointegration with further deposition of complex Mg-Ca phosphates/carbonates typical of natural bone. Finally, the implant was placed in a critical-size ulna defect in live rabbits, which lead to radiographic union and partial restoration of biomechanical strength in the defect. This study demonstrated that a thin sheet of coated Mg alloy that was spirally wrapped wound be a promising orthopedic biomaterial for bone repair. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.