How to cite this article: Jang T-S, Lee E-J, Jo J-H, Jeon J-M, Kim M-Y, Kim H-E, Koh Y-H. 2012. Fibrous membrane of nano-hybrid poly-L-lactic acid/silica xerogel for guided bone regeneration. J Biomed Mater Res Part B 2012:100B:321–330.
Fibrous membrane of nano-hybrid poly-L-lactic acid/silica xerogel for guided bone regeneration†
Article first published online: 21 NOV 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 100B, Issue 2, pages 321–330, February 2012
How to Cite
Jang, T.-S., Lee, E.-J., Jo, J.-H., Jeon, J.-M., Kim, M.-Y., Kim, H.-E. and Koh, Y.-H. (2012), Fibrous membrane of nano-hybrid poly-L-lactic acid/silica xerogel for guided bone regeneration. J. Biomed. Mater. Res., 100B: 321–330. doi: 10.1002/jbm.b.31952
- Issue published online: 4 JAN 2012
- Article first published online: 21 NOV 2011
- Manuscript Accepted: 3 AUG 2011
- Manuscript Revised: 26 MAY 2011
- Manuscript Received: 20 SEP 2010
- WCU (World Class University) project through National Research Foundation of Korea funded by the Ministry of Education, Science and Technology. Grant Number: R31-2008-000-10075-0
- Fundamental R&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea
- poly(L-lactic acid);
- silica xerogel;
- guided bone regeneration;
- hybrid membrane
Nanofibrous membranes, consisting of a poly(L-lactic acid) (PLLA)-silica xerogel hybrid material, were successfully fabricated from a hybrid sol using the electrospinning technique for guided bone regeneration (GBR) application. These hybrid nanofibers exhibited a homogeneous and continuous morphology, with a nano-sized dispersed silica xerogel phase in the PLLA fiber matrix. The mechanical properties, such as the tensile strength and the elastic modulus, were improved as the silica xerogel content increased up to 40%. All of the hybrid membranes exhibited highly hydrophilic surfaces and good proliferation levels. After culturing for 13 days, the cells that were cultured on the hybrid membranes exhibited a significantly higher ALP activity compared to the pure PLLA membrane. Moreover, the in vivo animal experiments that used the rat calvarial defect model revealed a remarkably improved bone regeneration ability for the hybrid membrane compared to pure PLLA. These results demonstrated the feasibility of these hybrid membranes for efficient GBR. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 321–330, 2012.