How to cite this article: Stadlinger B, Hintze V, Bierbaum S,Möller S, Schulz MC, Mai R, Kuhlisch E, Heinemann S, Scharnweber D, Schnabelrauch M, Eckelt U. 2012. Biological functionalization of dental implants with collagen and glycosaminoglycans—A comparative study. J Biomed Mater Res Part B 2012:100B:331–341.
Biological functionalization of dental implants with collagen and glycosaminoglycans—A comparative study†
Article first published online: 21 NOV 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 100B, Issue 2, pages 331–341, February 2012
How to Cite
Stadlinger, B., Hintze, V., Bierbaum, S., Möller, S., Schulz, M. C., Mai, R., Kuhlisch, E., Heinemann, S., Scharnweber, D., Schnabelrauch, M. and Eckelt, U. (2012), Biological functionalization of dental implants with collagen and glycosaminoglycans—A comparative study. J. Biomed. Mater. Res., 100B: 331–341. doi: 10.1002/jbm.b.31953
- Issue published online: 4 JAN 2012
- Article first published online: 21 NOV 2011
- Manuscript Accepted: 6 AUG 2011
- Manuscript Revised: 14 JUN 2011
- Manuscript Received: 20 FEB 2011
- German Research Foundation DFG (Deutsche Forschungsgemeinschaft). Grant Numbers: Transregio SFB 67, SCHN1099/1-1
- animal model;
- dental implant;
- extracellular matrix;
Biological implant surface coatings are an emerging technology to increase bone formation. Such an approach is of special interest in anatomical regions like the maxilla. In the present study, we hypothesized that the coating of titanium implants with components of the organic extracellular matrix increases bone formation and implant stability compared to an uncoated reference. The implants were coated using collagen-I with either two different concentrations of chondroitin sulfate (CS) or two differentially sulfated hyaluronans. Implant coatings were characterized biochemically and with atomic force microscopy. Histomorphometry was used to assess bone-implant contact (BIC) and bone-volume density (BVD) after 4 and 8 weeks of submerged healing in the maxilla of 20 minipigs. Further, implant stability was measured by resonance frequency analysis (RFA). Implants containing the lower CS concentration had significantly more BIC, compared to the uncoated reference at both times of interest. No significant increase was measured from week 4 to 8. Differences in BVD and RFA were statistically not significant. A higher concentration of CS and the application of sulfated hyaluronans showed no comparable increase in BIC. This study demonstrates a positive effect of a specific collagen–glycosaminoglycan combination on early bone formation in vivo. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 331–341, 2012.