How to cite this article: Morris DE, Mather ML, Simon CG Jr, Crowe JA. 2012. Time-optimized X-ray micro-CT imaging of polymer based scaffolds. J Biomed Mater Res Part B 2012:100B:360–367.
Time-optimized X-ray micro-CT imaging of polymer based scaffolds†
Article first published online: 24 NOV 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 100B, Issue 2, pages 360–367, February 2012
How to Cite
Morris, D. E., Mather, M. L., Simon, C. G. and Crowe, J. A. (2012), Time-optimized X-ray micro-CT imaging of polymer based scaffolds. J. Biomed. Mater. Res., 100B: 360–367. doi: 10.1002/jbm.b.31957
- Issue published online: 4 JAN 2012
- Article first published online: 24 NOV 2011
- Manuscript Accepted: 28 AUG 2011
- Manuscript Revised: 12 AUG 2011
- Manuscript Received: 17 MAY 2011
- Engineering and Physical Sciences Research Council, UK. Grant Number: EP/C534247/1
- scaffold characterization;
- image analysis;
- regenerative medicine
Although X-ray microscopic computed tomography is widely used to assess the structural properties of polymeric tissue scaffolds its validity is dependent on the quality of the images obtained. Here, the role of resolution, integration time, image averaging, and X-ray power on the accurate determination of scaffold porosity, while aiming to minimize imaging time, was investigated. This work identified key parameters for optimization and a methodology to vary them to improve results. Based on this, guidelines were developed to assist in the selection of image acquisition parameters to allow rapid and accurate scaffold imaging as required for mass manufacture. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 360–367, 2012.