How to cite this article: Tadier S, Bareille R, Siadous R, Marsan O, Charvillat C, Cazalbou S, Amédée J, Rey C, Combes C. 2012. Strontium-loaded mineral bone cements as sustained release systems: Compositions, release properties, and effects on human osteoprogenitor cells. J Biomed Mater Res Part B 2012:100B:378–;390.
Strontium-loaded mineral bone cements as sustained release systems: Compositions, release properties, and effects on human osteoprogenitor cells †
Version of Record online: 21 NOV 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 100B, Issue 2, pages 378–390, February 2012
How to Cite
Tadier, S., Bareille, R., Siadous, R., Marsan, O., Charvillat, C., Cazalbou, S., Amédée, J., Rey, C. and Combes, C. (2012), Strontium-loaded mineral bone cements as sustained release systems: Compositions, release properties, and effects on human osteoprogenitor cells . J. Biomed. Mater. Res., 100B: 378–390. doi: 10.1002/jbm.b.31959
- Issue online: 4 JAN 2012
- Version of Record online: 21 NOV 2011
- Manuscript Accepted: 14 AUG 2011
- Manuscript Revised: 4 AUG 2011
- Manuscript Received: 12 APR 2011
- bone cement;
- drug release;
- cell culture
This study aims to evaluate in vitro the release properties and biological behavior of original compositions of strontium (Sr)-loaded bone mineral cements. Strontium was introduced into vaterite CaCO3-dicalcium phosphate dihydrate cement via two routes: as SrCO3 in the solid phase (SrS cements), and as SrCl2 dissolved in the liquid phase (SrL cements), leading to different cement compositions after setting. Complementary analytical techniques implemented to thoroughly investigate the release/dissolution mechanism of Sr-loaded cements at pH 7.4 and 37°C during 3 weeks revealed a sustained release of Sr and a centripetal dissolution of the more soluble phase (vaterite) limited by a diffusion process. In all cases, the initial burst of the Ca and Sr release (highest for the SrL cements) that occurred over 48 h did not have a significant effect on the expression of bone markers (alkaline phosphatase, osteocalcin), the levels of which remained overexpressed after 15 days of culture with human osteoprogenitor (HOP) cells. At the same time, proliferation of HOP cells was significantly higher on SrS cements. Interestingly, this study shows that we can optimize the sustained release of Sr2+, the cement biodegradation and biological activity by controlling the route of introduction of strontium in the cement paste. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 378–390, 2012.