How to cite this article: Alexander BR, Murphy KE, Gallagher J, Farrell GF, Taggart G. 2012. Gelation time, homogeneity, and rupture testing of alginate-calcium carbonate-hydrogen peroxide gels for use as wound dressings. J Biomed Mater Res Part B 2012:100B:425–431.
Gelation time, homogeneity, and rupture testing of alginate-calcium carbonate-hydrogen peroxide gels for use as wound dressings†
Article first published online: 25 NOV 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 100B, Issue 2, pages 425–431, February 2012
How to Cite
Alexander, B. R., Murphy, K. E., Gallagher, J., Farrell, G. F. and Taggart, G. (2012), Gelation time, homogeneity, and rupture testing of alginate-calcium carbonate-hydrogen peroxide gels for use as wound dressings. J. Biomed. Mater. Res., 100B: 425–431. doi: 10.1002/jbm.b.31965
- Issue published online: 4 JAN 2012
- Article first published online: 25 NOV 2011
- Manuscript Accepted: 3 AUG 2011
- Manuscript Received: 19 MAY 2011
- wound dressing;
- alginate gel;
- hydrogen peroxide;
- hyaluronic acid;
- rupture characteristics
The care of chronic wounds carries a heavy financial burden on the healthcare industry, with billons being spent annually on their treatment. This, coupled with a decreased quality of life for sufferers, has led to a real urgency in developing inexpensive wound dressings that promote wound healing. Alginate gels for application as wound dressings were formed by varying alginate (0%–6% w/v), calcium carbonate (0%–1% w/v), hydrogen peroxide (0%–3.75% v/v), and hyaluronic acid (0–1.25 mg/L) content. The aging effects on the physical properties of the gels over a 14-day period were also investigated. The results indicated that the concentration of calcium carbonate and hydrogen peroxide, as well as sample age, all had a significant effect on the rupture characteristics and gelation time of the gels. Increased calcium carbonate content caused an increase in rupture force and rupture energy values, whereas increased hydrogen peroxide content and sample age resulted in a decrease in rupture force and rupture energy measurements. Increased calcium carbonate and hydrogen peroxide content produced a decrease in the time required for gel formation. Statistical models were also produced to provide a means of estimating rupture characteristics and gelation times for gels containing other concentrations of these components. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 425–431, 2012.