How to cite this article: Baker MI, Walsh SP, Schwartz Z, Boyan BD. 2012. A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications. J Biomed Mater Res Part B 2012:100B:1451–1457.
A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications †
Article first published online: 19 APR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 100B, Issue 5, pages 1451–1457, July 2012
How to Cite
Baker, M. I., Walsh, S. P., Schwartz, Z. and Boyan, B. D. (2012), A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications . J. Biomed. Mater. Res., 100B: 1451–1457. doi: 10.1002/jbm.b.32694
- Issue published online: 6 JUN 2012
- Article first published online: 19 APR 2012
- Manuscript Accepted: 29 JAN 2012
- Manuscript Revised: 20 JAN 2012
- Manuscript Received: 12 AUG 2011
- polyvinyl alcohol;
- cartilage replacement;
Polyvinyl alcohol (PVA) is a synthetic polymer derived from polyvinyl acetate through partial or full hydroxylation. PVA is commonly used in medical devices due to its low protein adsorption characteristics, biocompatibility, high water solubility, and chemical resistance. Some of the most common medical uses of PVA are in soft contact lenses, eye drops, embolization particles, tissue adhesion barriers, and as artificial cartilage and meniscus. The purpose of this review is to evaluate the available published information on PVA with respect to its safety as a medical device implant material for cartilage replacement. The review includes historical clinical use of PVA in orthopedics, and in vitro and in vivo biocompatibility studies. Finally, the safety recommendation involving the further development of PVA cryogels for cartilage replacement is addressed. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2012.