Biocompatibility and strength retention of biodegradable Mg-Ca-Zn alloy bone implants

Authors

  • Sung Youn Cho,

    1. Department of Mechanical Engineering, Korea University, Seongbuk, Anam-dong, Seoul 136-713, Republic of Korea
    2. Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 136-791, Republic of Korea
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  • Soo-Won Chae,

    Corresponding author
    1. Department of Mechanical Engineering, Korea University, Seongbuk, Anam-dong, Seoul 136-713, Republic of Korea
    • Department of Mechanical Engineering, Korea University, Seongbuk, Anam-dong, Seoul 136-713, Republic of Korea
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  • Kui Won Choi,

    1. Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 136-791, Republic of Korea
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  • Hyun Kwang Seok,

    1. Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 136-791, Republic of Korea
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  • Yu Chan Kim,

    1. Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 136-791, Republic of Korea
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  • Jae Young Jung,

    1. Advanced Analysis Center, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 136-791, Republic of Korea
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  • Seok Jo Yang,

    1. Department of Mechatronics Engineering, Chungnam National University, Yuseong, Daehak-ro, Daejeon 305-764, Korea
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  • Gyeong Je Kwon,

    1. Division of L'DISQ and Biodegradable Metal, U&i Corporation, Yonghyun-dong, Uijongbu 480-050, Korea
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  • Jong Tack Kim,

    1. Division of L'DISQ and Biodegradable Metal, U&i Corporation, Yonghyun-dong, Uijongbu 480-050, Korea
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  • Michel Assad

    1. Orthopedics and Biomaterials Laboratory, AccelLAB Inc., Boisbriand, Quebec, Canada
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  • How to cite this article: Cho SY, Chae S-W, Choi KW, Seok HK, Kim YC, Jung JY, Yang SJ, Kwon GJ, Kim JT, Assad M. 2013. Biocompatibility and strength retention of biodegradable Mg-Ca-Zn alloy bone implants. J Biomed Mater Res Part B 2013:101B:201–212.

Abstract

The biocompatibility and strength retention of a Mg-Ca-Zn alloy were studied to evaluate its efficacy for osteosynthesis applications. Mg-Ca-Zn alloy and self-reinforced poly l-lactide (SR-PLLA) bone screws were implanted into New Zealand rabbits for radiography analysis, micro computed tomography analysis, histomorphometry, hematology, serum biochemistry, histopathology, and inductively coupled plasma mass spectrometry analysis. Bending and torsion tests were performed on intact specimens to find the initial mechanical strength of these Mg-Ca-Zn alloy bone screws. Strength retention of the Mg-Ca-Zn alloy implants were calculated from in vivo degradation rates and initial mechanical strength. Based on the animal study, Mg-Ca-Zn alloy bone screw showed absence of subcutaneous gas pockets, characteristic surface erosion properties, faster degradation rate than SR-PLLA bone screw, normal reference range of hematology and serum biochemistry, better histopathological response than SR-PLLA bone screw, and stable concentrations of each constituent element in soft tissues surrounding the implants. The initial strength and strength retention of Mg-Ca-Zn alloy were compared with those of various biomaterials. The initial strength of Mg-Ca-Zn alloy was higher than those of biostable and biodegradable polymers. The strength retention of Mg-Ca-Zn alloy bone screws was similar to those of biodegradable polymer. Therefore, this Mg-Ca-Zn alloy represents an excellent biodegradable biomaterial candidate for osteosynthesis applications. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.

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