How to cite this article: Pilliar RM, Kandel RA, Grynpas MD, Hu Y. 2013. Porous calcium polyphosphate as load-bearing bone substitutes: In vivo study. J Biomed Mater Res Part B 2013:101B:1–8.
Porous calcium polyphosphate as load-bearing bone substitutes: In vivo study†
Article first published online: 10 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 101B, Issue 1, pages 1–8, January 2013
How to Cite
Pilliar, R. M., Kandel, R. A., Grynpas, M. D. and Hu, Y. (2013), Porous calcium polyphosphate as load-bearing bone substitutes: In vivo study. J. Biomed. Mater. Res., 101B: 1–8. doi: 10.1002/jbm.b.32832
- Issue published online: 13 DEC 2012
- Article first published online: 10 NOV 2012
- Manuscript Revised: 20 AUG 2012
- Manuscript Accepted: 20 AUG 2012
- Manuscript Received: 24 MAY 2012
- Natural Sciences and Engineering Council of Canada
- the Canadian Institute for Health Research
- bone substitute;
- porous calcium polyphosphate;
- bone ingrowth;
Porous calcium polyphosphate (CPP) is being investigated for fabrication of novel biodegradable bone substitutes. In this study, porous CPP implants formed by conventional CPP powder packing and using a two-step sinter/anneal process was used to form 20 and 30 vol % porous samples displaying relatively high strength. These were implanted in rabbit femoral condyle sites to study their ability for secure fixation in prepared sites through bone ingrowth. Porous implants of 20 and 30 vol % porosity and displaying compressive strengths ∼80 and 35 MPa, respectively, were used. Bone ingrowth sufficient to allow secure implant fixation was observed by 6 weeks (∼19% bone ingrowth per available pore space for the 30 vol % and 13% for the 20 vol % porous implants). The results of the in vivo study suggest the potential usefulness of porous CPP as biodegradable bone substitutes/augments in high load-bearing skeletal regions. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 1–8, 2013.