How to cite this article: Son JS, Choi Y-A, Park E-K, Kwon T-Y, Kim K-H, Lee K-B. 2013. Drug delivery from hydroxyapatite-coated titanium surfaces using biodegradable particle carriers. J Biomed Mater Res Part B 2013:101B:247–257.
Drug delivery from hydroxyapatite-coated titanium surfaces using biodegradable particle carriers†
Version of Record online: 10 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 101B, Issue 2, pages 247–257, February 2013
How to Cite
Son, J. S., Choi, Y.-A., Park, E.-K., Kwon, T.-Y., Kim, K.-H. and Lee, K.-B. (2013), Drug delivery from hydroxyapatite-coated titanium surfaces using biodegradable particle carriers. J. Biomed. Mater. Res., 101B: 247–257. doi: 10.1002/jbm.b.32834
- Issue online: 8 JAN 2013
- Version of Record online: 10 NOV 2012
- Manuscript Accepted: 11 SEP 2012
- Manuscript Revised: 6 SEP 2012
- Manuscript Received: 22 MAR 2012
- National Research Foundation of Korea Grant funded by the Korean Government. Grant Number: NRF-2010-013-E00024
- drug delivery
The goal of this study was to develop a functional titanium (Ti) implant loaded with bioactive molecules using biodegradable polymeric particles as drug delivery carrier for dental applications. In this study, dexamethasone (DEX)-loaded poly(lactic-co-glycolic acid) (PLGA) particles were electrostatically immobilized on a Ti disc surface coated with hydroxyapatite (HA) nanocrystals using a low temperature high speed collision (LTHSC) method. Resorbable blasting media (RBM) Ti discs (S1), HA-Ti discs (S2), and HA-Ti discs treated with DEX-loaded PLGA particles (S3) were fabricated in this study as sample discs. To facilitate surface immobilization, PLGA particles were coated with polyethyleneimine (PEI) to produce a positive surface charge. This modification of PLGA particle surfaces, allowed DEX-loaded PLGA particles to be immobilized on negatively charged S2 disc surface. It was found that DEX-loaded PLGA particles were well dispersed and immobilized onto the S3 disc surfaces. Release profile studies of DEX from S3 discs in a 4-week immersion study indicated an initial burst release followed by sustained release. In vitro evaluation of bone marrow derived mesenchymal stem cells (BMSCs) cultured for 1 and 2 weeks on S3 discs showed greater BMSC differentiation than on S1 or S2 discs, demonstrating that this innovative delivery platform potently induced BMSC differentiation in vitro, and suggesting that it could be exploited for stem cell therapy purposes or to enhance in vivo osteogenesis. In addition, the results of the present study shows that various bioactive molecules that promote bone regeneration can be efficiently incorporated onto HA-Ti surfaces using biodegradable polymeric particles. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.