Get access

Low elastic modulus contributes to the osteointegration of titanium alloy plug

Authors

  • Yongquan Zhang,

    1. Department of Orthopedic Oncology, Xi-Jing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Junlin Wang,

    1. School of Stomatology, The Fourth Military Medical University, Xi'an, People's Republic of China
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Pan Wang,

    1. Department of Orthopedic Oncology, Xi-Jing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China
    Search for more papers by this author
  • Xiangli Fan,

    1. Department of Orthopedic Oncology, Xi-Jing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China
    Search for more papers by this author
  • Xiaokang Li,

    1. Department of Orthopedic Oncology, Xi-Jing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China
    Search for more papers by this author
  • Jun Fu,

    1. Department of Orthopedic Oncology, Xi-Jing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China
    Search for more papers by this author
  • Shujun Li,

    1. Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, People's Republic of China
    Search for more papers by this author
  • Hongbin Fan,

    Corresponding author
    1. Department of Orthopedic Oncology, Xi-Jing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China
    • Department of Orthopedic Oncology, Xi-Jing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China
    Search for more papers by this author
  • Zheng Guo

    Corresponding author
    1. Department of Orthopedic Oncology, Xi-Jing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China
    • Department of Orthopedic Oncology, Xi-Jing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China
    Search for more papers by this author

  • How to cite this article: Zhang Y, Wang J, Wang P, Fan X, Li X, Fu J, Li S, Fan H, Guo Z. 2013. Low elastic modulus contributes to the osteointegration of titanium alloy plug. J Biomed Mater Res Part B 2013:101B:584–590.

Abstract

Resurfacing of cartilage defect with mini titanium plug is considered a promising alternative for the treatment of focal chondral defects. Elastic modulus of the metal implant plays a significant role in force transmission which influences the stability of plug. This study assessed the effects of two kinds of titanium alloy plug with different elastic modulus, that is, titanium 2448 (Ti2448) plug and titanium–6 aluminum–4 vanadium (TAV) plug on osteointegration. The full-thickness chondral defects were created in bilateral knees of dogs and then TAV and Ti2448 plugs were implanted, respectively. After 12 weeks, radiographic evaluation did not reveal any signs of disassembly, subsidence, or periprosthetic radiolucency in both groups. Microcomputed tomography analysis revealed that bone histomorphometric parameters in Ti2448 group were all significantly better than those of TAV group. Furthermore, the value of pullout force in Ti2448 group was also significantly higher. Histology showed that the screw threads of Ti2448 plug were well integrated into the newly formed bone. In contrast, the trabecular bone was sparsely distributed around TAV plug. In conclusion, Ti2448 plug with low elastic modulus showed more favorable characteristics in osteointegration. Ti2448 may be a promising biomaterial for fabricating mini plug applied for cartilage resurfacing. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.

Ancillary