How to cite this article: Yusong P, Qianqian S, Chengling P, Jing W. 2013. Prediction of mechanical properties of multilayer gradient hydroxyapatite reinforced poly(vinyl alcohol) gel biomaterial. J Biomed Mater Res Part B 2013:101B:729–735.
Prediction of mechanical properties of multilayer gradient hydroxyapatite reinforced poly(vinyl alcohol) gel biomaterial†
Article first published online: 29 JAN 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 101B, Issue 5, pages 729–735, July 2013
How to Cite
Yusong, P., Qianqian, S., Chengling, P. and Jing, W. (2013), Prediction of mechanical properties of multilayer gradient hydroxyapatite reinforced poly(vinyl alcohol) gel biomaterial. J. Biomed. Mater. Res., 101B: 729–735. doi: 10.1002/jbm.b.32875
- Issue published online: 8 JUN 2013
- Article first published online: 29 JAN 2013
- Manuscript Accepted: 25 NOV 2012
- Manuscript Revised: 19 NOV 2012
- Manuscript Received: 29 AUG 2012
- National Natural Science Foundation of China. Grant Number: Project No. 51175004
- Natural Science Research of key projects of Anhui Provincial Universities. Grant Number: Project No.KJ2010A099
- multilayer gradient HA/PVA gel composites;
- compressive strength;
- mechanical model
Functional graded materials provided us one new concept for artificial articular cartilage design with graded component and graded structure. In this article, a novel functional material design was proposed by functionalizing hydroxyapatite (HA) particles in poly(vinyl alcohol) (PVA) hydrogel. The goal of the present study was to fabricate a multilayer gradient HA/PVA gel biocomposites through layer-by-layer casting method combining with freeze/thaw cycle technology and establish a mechanical model to predict the compressive mechanical properties of multilayer gradient gel biocomposites. The results showed that the compressive strength of the multilayer gradient gel biocomposites increased with the rise of HA content, but it presented decreasing trend with the rise of interlayer gradient concentration of HA particles. Furthermore, the compressive strength of multilayer gradient biocomposites would be approximately predicted by the established mechanical model. The maximum error between theoretical compressive strength predicted by the model and the experimental strength is less than 7%. On the other hand, the compressive mechanical properties of multilayer gradient composites could be designed and controlled by the mechanical model as established in this study. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.