How to cite this article: Wang L, Yoon DM, Spicer PP, Henslee AM, Scott DW, Wong ME, Kasper FK, Mikos AG. 2013. Characterization of porous polymethylmethacrylate space maintainers for craniofacial reconstruction. J Biomed Mater Res Part B 2013:101B:813–825.
Characterization of porous polymethylmethacrylate space maintainers for craniofacial reconstruction†
Article first published online: 29 JAN 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 101B, Issue 5, pages 813–825, July 2013
How to Cite
Wang, L., Yoon, D. M., Spicer, P. P., Henslee, A. M., Scott, D. W., Wong, M. E., Kasper, F. K. and Mikos, A. G. (2013), Characterization of porous polymethylmethacrylate space maintainers for craniofacial reconstruction. J. Biomed. Mater. Res., 101B: 813–825. doi: 10.1002/jbm.b.32885
- Issue published online: 8 JUN 2013
- Article first published online: 29 JAN 2013
- Manuscript Accepted: 29 NOV 2012
- Manuscript Revised: 2 NOV 2012
- Manuscript Received: 23 MAY 2012
- Armed Forces Institute of Regenerative Medicine. Grant Number: W81XWH-08-2-0032
- National Science Foundation. Grant Number: DMS-09-07491.
- porous polymethylmethacrylate;
- space maintainer;
- craniofacial reconstruction
Porous polymethylmethacrylate (PMMA) has been used as an alloplastic bone substitute in the craniofacial complex, showing integration with the surrounding soft and hard tissue. This study investigated the physicochemical properties of curing and cured mixtures of a PMMA-based bone cement and a carboxymethylcellulose (CMC) gel porogen. Four formulations yielding porous PMMA of varied porosity were examined; specifically, two groups containing 30% (w/w) CMC gel in the mixture using a 7% (w/v) or 9% (w/v) stock CMC gel (30-7 and 30-9, respectively) and two groups containing 40% (w/w) CMC gel (40-7 and 40-9). An additional group comprising solid PMMA without CMC was investigated. The incorporation of the CMC gel into the PMMA bone cement during polymerization decreased the setting time from 608 ± 12 s for the solid PMMA to 427 ± 10 s for the 40-9 group, and decreased the maximum temperature from 81 ± 4°C for the solid PMMA to 38 ± 2°C for the 40-9 group. The porous PMMA groups exhibited reduced compressive strength and bending modulus and strength relative to the solid PMMA. All the porous PMMA formulations released more unconverted methylmethacrylate (MMA) monomer and N,N-dimethyl-p-toluidine (DMT) from cured specimens and less MMA and DMT from curing specimens than the solid PMMA. The data suggest that the physicochemical properties of the porous PMMA formulations are appropriate for their application in craniofacial space maintenance. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.