Both authors contributed equally to this work.
Analysis of wear, wear particles, and reduced inflammatory potential of vitamin E ultrahigh-molecular-weight polyethylene for use in total joint replacement†
Version of Record online: 22 FEB 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Volume 101B, Issue 3, pages 458–466, April 2013
How to Cite
Bladen, C. L., Teramura, S., Russell, S. L., Fujiwara, K., Fisher, J., Ingham, E., Tomita, N. and Tipper, J. L. (2013), Analysis of wear, wear particles, and reduced inflammatory potential of vitamin E ultrahigh-molecular-weight polyethylene for use in total joint replacement. J. Biomed. Mater. Res., 101B: 458–466. doi: 10.1002/jbm.b.32904
How to cite this article: Bladen CL, Teramura S, Russell SL, Fujiwara K, Fisher J, Ingham E, Tomita N, Tipper JL. 2013. Analysis of wear, wear particles, and reduced inflammatory potential of vitamin E ultrahigh-molecular-weight polyethylene for use in total joint replacement. J Biomed Mater Res Part B 2013:101B:458–466.
- Issue online: 18 MAR 2013
- Version of Record online: 22 FEB 2013
- Manuscript Accepted: 10 JAN 2013
- Manuscript Revised: 27 NOV 2012
- Manuscript Received: 9 JAN 2012
- WELMEC, a Centre of Excellence in Medical Engineering, Wellcome Trust and EPSRC. Grant Number: WT 088908/Z/09/Z
- vitamin E;
- oxidative damage;
- oxidative stress;
- osteolytic mediators;
- novel bearing materials
Vitamin E (VE) has been added to ultrahigh-molecular-weight polyethylene (UHMWPE) acetabular cups and tibial trays primarily to reduce oxidative damage to the polymer. The aim of this study was to investigate the relative wear rates of UHMWPE-containing VE compared with virgin UHMWPE. The ability of VE to reduce the amount of inflammatory cytokines produced from stimulated peripheral blood mononuclear cells (PBMNCs) was also investigated. Stimulation was achieved by exposure of PBMNCs to either lipoplysaccharide (LPS) or VE-containing UHMWPE (VE-UHMWPE). In the present study, results showed that the wear rates of UHMWPE with or without VE were not significantly different. Particles generated by UHMWPE with and without VE were not significantly different in size distribution. The production of osteolytic mediators, tumor necrosis factor-alpha, interleukin 1β (IL-β), IL-6, and IL-8 were significantly reduced in (PBMNCs) stimulated with either LPS + VE compared with LPS or VE-UHMWPE particles compared to virgin UHMWPE particles. This trend was also observed when VE was added as a liquid to UHMWPE wear particle-stimulated PBMNCs. The exact mechanism of how VE affects the release of inflammatory mediators from particle-stimulated macrophages is not yet understood. It is likely to involve the anti-inflammatory and/or antioxidant effects of VE. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 458–466, 2013.